In this cohort of 282 pregnancies, pre-eclampsia prevalence was not significantly increased (4.6% [95% C.I 2.2-7.0%] versus population prevalence of 4.6% [95% C.I. 2.7-8.2], p=0.99); 12/13 women had concurrent obstetric/medical risk factors for pre-eclampsia. The prevalence of preterm pre-eclampsia (
To conclude, this study demonstrated a modest increase in preterm pre-eclampsia and significant increase in FGR in women with pre-existing cardiac dysfunction. Our results do not necessarily support a causal relationship between cardiac dysfunction and pre-eclampsia, especially given the population’s background risk status. The mechanism underpinning the relationship between cardiac dysfunction and FGR merits further research but could be influenced by concomitant ß blocker use.
|Publication status||Published - 4 Jan 2023|
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Seeking a treatment to improve heart function and reduce future cardiovascular risk for women diagnosed with pre-eclampsia during their pregnancy (Enalapril)
Laura Ormesher (Participant), Edward Johnstone (Participant), Jenny Myers (Participant), Elizabeth Cottrell (Participant) & Andrew Trafford (Participant)
Impact: Health and wellbeing