Prevalence of pre-eclampsia and adverse pregnancy outcomes in women with pre-existing cardiomyopathy: a multi-centre retrospective cohort study

Laura Ormesher; Sarah Vause; Suzanne Higson; Anna Roberts; Bernard Clarke; Stephanie Curtis; Victoria Ordonez; Faiza Ansari; Thomas R. Everett; Claire Hordern; Lucy Mackillop; Victoria Stern; Tessa Bonnett; Alice Reid; Suzanne K. Wallace; Ebruba Oyekan; Hannah Douglas; Matthew Cauldwell; Maya Reddy; Kirsten Palmer; Maggie Simpson; Janet Brennand; Laura Minns; Leisa Freeman; Sarah Murray; Nirmala Mary; James Castleman; Katie R. Morris; Elizabeth Haslett; Christopher Cassidy; Edward Johnstone; Jenny Myers

doi:10.1038/s41598-022-26606-z

Prevalence of pre-eclampsia and adverse pregnancy outcomes in women with pre-existing cardiomyopathy: a multi-centre retrospective cohort study

Laura Ormesher, Sarah Vause, Suzanne Higson, Anna Roberts, Bernard Clarke, Stephanie Curtis, Victoria Ordonez, Faiza Ansari, Thomas R. Everett, Claire Hordern, Lucy Mackillop, Victoria Stern, Tessa Bonnett, Alice Reid, Suzanne K. Wallace, Ebruba Oyekan, Hannah Douglas, Matthew Cauldwell, Maya Reddy, Kirsten PalmerMaggie Simpson, Janet Brennand, Laura Minns, Leisa Freeman, Sarah Murray, Nirmala Mary, James Castleman, Katie R. Morris, Elizabeth Haslett, Christopher Cassidy, Edward Johnstone, Jenny Myers

Research output: Contribution to journal › Article › peer-review

Abstract

Pre-eclampsia is associated with postnatal cardiac dysfunction; however, the nature of this relationship remains uncertain. This multicentre retrospective cohort study aimed to determine the prevalence of pre-eclampsia in women with pre-existing cardiac dysfunction (left ventricular ejection fraction
In this cohort of 282 pregnancies, pre-eclampsia prevalence was not significantly increased (4.6% [95% C.I 2.2-7.0%] versus population prevalence of 4.6% [95% C.I. 2.7-8.2], p=0.99); 12/13 women had concurrent obstetric/medical risk factors for pre-eclampsia. The prevalence of preterm pre-eclampsia (
To conclude, this study demonstrated a modest increase in preterm pre-eclampsia and significant increase in FGR in women with pre-existing cardiac dysfunction. Our results do not necessarily support a causal relationship between cardiac dysfunction and pre-eclampsia, especially given the population’s background risk status. The mechanism underpinning the relationship between cardiac dysfunction and FGR merits further research but could be influenced by concomitant ß blocker use.

Original language	English
Article number	153
Journal	Scientific Reports
Volume	13
DOIs	https://doi.org/10.1038/s41598-022-26606-z
Publication status	Published - 4 Jan 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41598-022-26606-z

Seeking a treatment to improve heart function and reduce future cardiovascular risk for women diagnosed with pre-eclampsia during their pregnancy (Enalapril)
Ormesher, L. (Corresponding participant), Johnstone, E. (Participant), Myers, J. (Participant), Cottrell, E. (Participant) & Trafford, A. (Participant)
Impact: Health and wellbeing

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Ormesher, L., Vause, S., Higson, S., Roberts, A., Clarke, B., Curtis, S., Ordonez, V., Ansari, F., Everett, T. R., Hordern, C., Mackillop, L., Stern, V., Bonnett, T., Reid, A., Wallace, S. K., Oyekan, E., Douglas, H., Cauldwell, M., Reddy, M., ... Myers, J. (2023). Prevalence of pre-eclampsia and adverse pregnancy outcomes in women with pre-existing cardiomyopathy: a multi-centre retrospective cohort study. Scientific Reports, 13, Article 153 . https://doi.org/10.1038/s41598-022-26606-z

@article{8543bdebd7e040e3a4ad6108e8ab1a93,

title = "Prevalence of pre-eclampsia and adverse pregnancy outcomes in women with pre-existing cardiomyopathy: a multi-centre retrospective cohort study",

abstract = "Pre-eclampsia is associated with postnatal cardiac dysfunction; however, the nature of this relationship remains uncertain. This multicentre retrospective cohort study aimed to determine the prevalence of pre-eclampsia in women with pre-existing cardiac dysfunction (left ventricular ejection fraction In this cohort of 282 pregnancies, pre-eclampsia prevalence was not significantly increased (4.6% [95% C.I 2.2-7.0%] versus population prevalence of 4.6% [95% C.I. 2.7-8.2], p=0.99); 12/13 women had concurrent obstetric/medical risk factors for pre-eclampsia. The prevalence of preterm pre-eclampsia (To conclude, this study demonstrated a modest increase in preterm pre-eclampsia and significant increase in FGR in women with pre-existing cardiac dysfunction. Our results do not necessarily support a causal relationship between cardiac dysfunction and pre-eclampsia, especially given the population{\textquoteright}s background risk status. The mechanism underpinning the relationship between cardiac dysfunction and FGR merits further research but could be influenced by concomitant {\ss} blocker use.",

author = "Laura Ormesher and Sarah Vause and Suzanne Higson and Anna Roberts and Bernard Clarke and Stephanie Curtis and Victoria Ordonez and Faiza Ansari and Everett, {Thomas R.} and Claire Hordern and Lucy Mackillop and Victoria Stern and Tessa Bonnett and Alice Reid and Wallace, {Suzanne K.} and Ebruba Oyekan and Hannah Douglas and Matthew Cauldwell and Maya Reddy and Kirsten Palmer and Maggie Simpson and Janet Brennand and Laura Minns and Leisa Freeman and Sarah Murray and Nirmala Mary and James Castleman and Morris, {Katie R.} and Elizabeth Haslett and Christopher Cassidy and Edward Johnstone and Jenny Myers",

year = "2023",

month = jan,

day = "4",

doi = "10.1038/s41598-022-26606-z",

language = "English",

volume = "13",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Research",

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Ormesher, L, Vause, S, Higson, S, Roberts, A, Clarke, B, Curtis, S, Ordonez, V, Ansari, F, Everett, TR, Hordern, C, Mackillop, L, Stern, V, Bonnett, T, Reid, A, Wallace, SK, Oyekan, E, Douglas, H, Cauldwell, M, Reddy, M, Palmer, K, Simpson, M, Brennand, J, Minns, L, Freeman, L, Murray, S, Mary, N, Castleman, J, Morris, KR, Haslett, E, Cassidy, C, Johnstone, E & Myers, J 2023, 'Prevalence of pre-eclampsia and adverse pregnancy outcomes in women with pre-existing cardiomyopathy: a multi-centre retrospective cohort study', Scientific Reports, vol. 13, 153 . https://doi.org/10.1038/s41598-022-26606-z

TY - JOUR

T1 - Prevalence of pre-eclampsia and adverse pregnancy outcomes in women with pre-existing cardiomyopathy: a multi-centre retrospective cohort study

AU - Ormesher, Laura

AU - Vause, Sarah

AU - Higson, Suzanne

AU - Roberts, Anna

AU - Clarke, Bernard

AU - Curtis, Stephanie

AU - Ordonez, Victoria

AU - Ansari, Faiza

AU - Everett, Thomas R.

AU - Hordern, Claire

AU - Mackillop, Lucy

AU - Stern, Victoria

AU - Bonnett, Tessa

AU - Reid, Alice

AU - Wallace, Suzanne K.

AU - Oyekan, Ebruba

AU - Douglas, Hannah

AU - Cauldwell, Matthew

AU - Reddy, Maya

AU - Palmer, Kirsten

AU - Simpson, Maggie

AU - Brennand, Janet

AU - Minns, Laura

AU - Freeman, Leisa

AU - Murray, Sarah

AU - Mary, Nirmala

AU - Castleman, James

AU - Morris, Katie R.

AU - Haslett, Elizabeth

AU - Cassidy, Christopher

AU - Johnstone, Edward

AU - Myers, Jenny

PY - 2023/1/4

Y1 - 2023/1/4

N2 - Pre-eclampsia is associated with postnatal cardiac dysfunction; however, the nature of this relationship remains uncertain. This multicentre retrospective cohort study aimed to determine the prevalence of pre-eclampsia in women with pre-existing cardiac dysfunction (left ventricular ejection fraction In this cohort of 282 pregnancies, pre-eclampsia prevalence was not significantly increased (4.6% [95% C.I 2.2-7.0%] versus population prevalence of 4.6% [95% C.I. 2.7-8.2], p=0.99); 12/13 women had concurrent obstetric/medical risk factors for pre-eclampsia. The prevalence of preterm pre-eclampsia (To conclude, this study demonstrated a modest increase in preterm pre-eclampsia and significant increase in FGR in women with pre-existing cardiac dysfunction. Our results do not necessarily support a causal relationship between cardiac dysfunction and pre-eclampsia, especially given the population’s background risk status. The mechanism underpinning the relationship between cardiac dysfunction and FGR merits further research but could be influenced by concomitant ß blocker use.

AB - Pre-eclampsia is associated with postnatal cardiac dysfunction; however, the nature of this relationship remains uncertain. This multicentre retrospective cohort study aimed to determine the prevalence of pre-eclampsia in women with pre-existing cardiac dysfunction (left ventricular ejection fraction In this cohort of 282 pregnancies, pre-eclampsia prevalence was not significantly increased (4.6% [95% C.I 2.2-7.0%] versus population prevalence of 4.6% [95% C.I. 2.7-8.2], p=0.99); 12/13 women had concurrent obstetric/medical risk factors for pre-eclampsia. The prevalence of preterm pre-eclampsia (To conclude, this study demonstrated a modest increase in preterm pre-eclampsia and significant increase in FGR in women with pre-existing cardiac dysfunction. Our results do not necessarily support a causal relationship between cardiac dysfunction and pre-eclampsia, especially given the population’s background risk status. The mechanism underpinning the relationship between cardiac dysfunction and FGR merits further research but could be influenced by concomitant ß blocker use.

U2 - 10.1038/s41598-022-26606-z

DO - 10.1038/s41598-022-26606-z

M3 - Article

SN - 2045-2322

VL - 13

JO - Scientific Reports

JF - Scientific Reports

M1 - 153

ER -

Prevalence of pre-eclampsia and adverse pregnancy outcomes in women with pre-existing cardiomyopathy: a multi-centre retrospective cohort study

Abstract

UN SDGs

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Impacts

Seeking a treatment to improve heart function and reduce future cardiovascular risk for women diagnosed with pre-eclampsia during their pregnancy (Enalapril)

Cite this