Prevalence of pre-eclampsia and adverse pregnancy outcomes in women with pre-existing cardiomyopathy: a multi-centre retrospective cohort study

Laura Ormesher, Sarah Vause, Suzanne Higson, Anna Roberts, Bernard Clarke, Stephanie Curtis, Victoria Ordonez, Faiza Ansari, Thomas R. Everett, Claire Hordern, Lucy Mackillop, Victoria Stern, Tessa Bonnett, Alice Reid, Suzanne K. Wallace, Ebruba Oyekan, Hannah Douglas, Matthew Cauldwell, Maya Reddy, Kirsten PalmerMaggie Simpson, Janet Brennand, Laura Minns, Leisa Freeman, Sarah Murray, Nirmala Mary, James Castleman, Katie R. Morris, Elizabeth Haslett, Christopher Cassidy, Edward Johnstone, Jenny Myers

Research output: Contribution to journalArticlepeer-review

Abstract

Pre-eclampsia is associated with postnatal cardiac dysfunction; however, the nature of this relationship remains uncertain. This multicentre retrospective cohort study aimed to determine the prevalence of pre-eclampsia in women with pre-existing cardiac dysfunction (left ventricular ejection fraction
In this cohort of 282 pregnancies, pre-eclampsia prevalence was not significantly increased (4.6% [95% C.I 2.2-7.0%] versus population prevalence of 4.6% [95% C.I. 2.7-8.2], p=0.99); 12/13 women had concurrent obstetric/medical risk factors for pre-eclampsia. The prevalence of preterm pre-eclampsia (
To conclude, this study demonstrated a modest increase in preterm pre-eclampsia and significant increase in FGR in women with pre-existing cardiac dysfunction. Our results do not necessarily support a causal relationship between cardiac dysfunction and pre-eclampsia, especially given the population’s background risk status. The mechanism underpinning the relationship between cardiac dysfunction and FGR merits further research but could be influenced by concomitant ß blocker use.
Original languageEnglish
Article number153
JournalScientific Reports
Volume13
DOIs
Publication statusPublished - 4 Jan 2023

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