Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function

Natalie C. Jones, Megan L. Lynn, Karin Gaudenz, Daisuke Sakai, Kazushi Aoto, Jean Phillipe Rey, Earl F. Glynn, Lacey Ellington, Chunying Du, Jill Dixon, Michael J. Dixon, Paul A. Trainor

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Treacher Collins syndrome (TCS) is a congenital disorder of craniofacial development arising from mutations in TCOF1, which encodes the nucleolar phosphoprotein Treacle. Haploinsufficiency of Tcof1 perturbs mature ribosome biogenesis, resulting in stabilization of p53 and the cyclin G1-mediated cell-cycle arrest that underpins the specificity of neuroepithelial apoptosis and neural crest cell hypoplasia characteristic of TCS. Here we show that inhibition of p53 prevents cyclin G1-driven apoptotic elimination of neural crest cells while rescuing the craniofacial abnormalities associated with mutations in Tcof1 and extending life span. These improvements, however, occur independently of the effects on ribosome biogenesis; thus suggesting that it is p53-dependent neuroepithelial apoptosis that is the primary mechanism underlying the pathogenesis of TCS. Our work further implies that neuroepithelial and neural crest cells are particularly sensitive to cellular stress during embryogenesis and that suppression of p53 function provides an attractive avenue for possible clinical prevention of TCS craniofacial birth defects and possibly those of other neurocristopathies. © 2008 Nature Publishing Group.
    Original languageEnglish
    Pages (from-to)125-133
    Number of pages8
    JournalNature Medicine
    Volume14
    Issue number2
    DOIs
    Publication statusPublished - Feb 2008

    Keywords

    • Animals
    • Apoptosis
    • Body Patterning
    • abnormalities: Bone and Bones
    • Cell Cycle
    • Chickens
    • metabolism: Cyclins
    • abnormalities: Embryo, Mammalian
    • Female
    • Humans
    • Male
    • prevention & control: Mandibulofacial Dysostosis
    • Mice
    • Mice, Inbred C57BL
    • abnormalities: Neural Crest
    • cytology: Neuroepithelial Cells
    • metabolism: Nuclear Proteins
    • metabolism: Phosphoproteins
    • metabolism: Ribosomes
    • genetics: Trans-Activation (Genetics)
    • antagonists & inhibitors: Tumor Suppressor Protein p53

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