Prevention Strategies in Endometrial Carcinoma

Michelle L. Mackintosh, Emma J. Crosbie

Research output: Contribution to journalReview articlepeer-review


Purpose of the Review
To assess the most recent high-quality evidence for endometrial cancer prevention strategies.

Recent Findings
Obesity is an established risk factor for endometrial cancer.

Weight cycling and weight gain in middle age are risk factors for endometrial cancer.

Bariatric surgery reduces the risk of endometrial cancer by up to 81% in obese women who attain and maintain a normal weight.

Combined oral contraceptives provide durable protection against endometrial cancer for 30 years or more.

Ever use of the levonorgestrel intrauterine system (LNG-IUS) and inert intrauterine devices reduce endometrial cancer risk.

The first oestrogen-based non-progestin HRT for non-hysterectomised women that contains estradiol and bazedoxifene has an effective protective effect on endometrium.

Bisphosphonates reduce endometrial cancer risk.

Weight loss and LNG-IUS would seem to be an effective strategy for preventing the development of obesity-driven endometrial cancer in the highest risk women. Future research may identify other safe and effective chemoprevention interventions, such as aspirin, bisphosphonates or metformin.
Original languageEnglish
Article number101
JournalCurrent Oncology Reports
Issue number12
Early online date13 Nov 2018
Publication statusE-pub ahead of print - 13 Nov 2018


  • Endometrial cancer
  • Obesity
  • Risk prediction
  • Prevention strategies
  • Weight loss
  • Levonorgestrel intrauterine system (LNG-IUS)


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