Principles of genetics and pharmacogenetics

W.G. Newman

doi:10.1007/978-90-481-8618-1_3

Principles of genetics and pharmacogenetics

W.G. Newman

Division of Evolution, Infection and Genomics

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This chapter will explain in brief the principles of genetics and genetic variation and how these apply to prediction of adverse drug reactions and treatment efficacy in cancer. The difference between germline (inherited) and somatic (acquired) genetic variation will be explained and its particular importance in cancer. Some of the different technologies that can now be used to detect genetic variation will be explained. This chapter will also examine how pharmacogenetic studies have been conducted and issues relating to study design comparing different approaches.

Original language	English
Title of host publication	Pharmacogenetics
Subtitle of host publication	Making cancer treatment safer and more effective
Editors	William G. Newman
Place of Publication	Dordrecht
Publisher	Springer Nature
Chapter	3
Pages	27-44
Number of pages	18
ISBN (Electronic)	9789048186181
ISBN (Print)	9789048186174
DOIs	https://doi.org/10.1007/978-90-481-8618-1_3
Publication status	Published - 3 Jun 2010

Keywords

genetics
germline variation
single nucleotide polymorphism (SNP)
somatic variation
pharmacogenetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-90-481-8618-1_3

Cite this

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KW - germline variation

KW - single nucleotide polymorphism (SNP)

KW - somatic variation

KW - pharmacogenetics

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Principles of genetics and pharmacogenetics

Abstract

Keywords

UN SDGs

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