Probiotics reduce the prevalence of oral Candida in the elderly a randomized controlled trial

K. Hatakka, A. J. Ahola, H. Yli-Knuuttila, M. Richardson, T. Poussa, J. H. Meurman, R. Korpela

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    Overgrowth of oral yeast is a common problem among the elderly. Probiotic bacteria are known to inhibit the growth of pathogenic microbes. We tested the hypothesis that cheese containing probiotic bacteria can reduce the prevalence of oral Candida. During this 16-week, randomized, double-blind, placebo-controlled study, 276 elderly people consumed daily 50 g of either probiotic (n = 136) or control cheese (n = 140). The primary outcome measure was the prevalence of a high salivary yeast count (≥ 10 4 cfu/mL) analyzed by the Dentocult® method. The prevalence decreased in the probiotic group from 30% to 21% (32% reduction), and increased in the control group from 28% to 34%. Probiotic intervention reduced the risk of high yeast counts by 75% (OR = 0.25, 95%CI 0.10-0.65, p = 0.004), and the risk of hyposalivation by 56% (OR = 0.44, 95%CI 0.19-1.01, p = 0.05). Thus, probiotic bacteria can be effective in controlling oral Candida and hyposalivation in the elderly.
    Original languageEnglish
    Pages (from-to)125-130
    Number of pages5
    JournalJournal of Dental Research
    Issue number2
    Publication statusPublished - Feb 2007


    • Candida
    • Hyposalivation
    • Lactobacillus GG
    • Probiotics
    • Randomized trial
    • The elderly


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