Process monitoring of an industrial fed-batch fermentation

B. Lennox, G. A. Montague, H. G. Hiden, G. Kornfeld, P. R. Goulding

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Market demand places great emphasis in industry on product quality. Consequently, process monitoring and control have become important aspects of systems engineering. In this article we detail the results of a 2-year study focusing on the development of a condition monitoring system for a fed-batch fermentation system operated by Biochemie Gmbh in Austria. We also demonstrate the suitability and limitations of current state of the art technologies in this field and suggest novel modifications and configurations to improve their suitability for application to a fed-batch fermentation system. © 2001 John Wiley & Sons, Inc.
    Original languageEnglish
    Pages (from-to)125-135
    Number of pages10
    JournalBiotechnology and Bioengineering
    Volume74
    Issue number2
    DOIs
    Publication statusPublished - 20 Jul 2001

    Keywords

    • Fault detection
    • Fault diagnosis
    • Fermentation
    • Multivariate statistical process control
    • Principal component analysis

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