Prodrug-activating systems in suicide gene therapy.

CJ Springer, I Niculescu-Duvaz

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Cancer chemotherapy encompasses a large number of well-documented and clinically established methods for the treatment of malignant diseases. However, the efficacy of these approaches is often hampered by an insufficient therapeutic index, lack of specificity, and the emergence of drug-resistant cell subpopulations. One approach aimed at enhancing the selectivity of cancer chemotherapy for solid tumors relies on the application of gene therapy technologies.
    Original languageEnglish
    Pages (from-to)1161-1167
    Number of pages7
    JournalThe Journal of clinical investigation
    Volume105
    Issue number9
    DOIs
    Publication statusPublished - May 2000

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