Production of [17F]CH3F (t1/2 = 65 s), an improved PET tracer for rCBF measurement

T. E. Barnhart; A. K. Converse; K. A. Dabbs; M. J. Schueller; C. K. Stone; R. J. Nickles; A. D. Roberts

Production of [17F]CH3F (t1/2 = 65 s), an improved PET tracer for rCBF measurement

T. E. Barnhart, A. K. Converse, K. A. Dabbs, M. J. Schueller, C. K. Stone, R. J. Nickles, A. D. Roberts

Research output: Contribution to journal › Article › peer-review

Abstract

Production of 17F (t1/2=65s) in the form of [17F] F2 has been achieved using both the 20Ne(p,α) 17F and 16O(d,n)17F reactions with 11 MeV protons and 6 MeV deuterons, respectively. Yields have proven suitable for subsequent radiosynthesis of the blood flow tracer, [17F]CH 3F (>60 mCi in saline), currently in use for fast repetition human studies of regional cerebral blood flow with positron emission tomography. Thick target yields of 15 mCi/μA for protons and 44 mCi/μA for deuterons have been measured for [17F]F2. © 2004 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	525-532
Number of pages	7
Journal	Applied Radiation and Isotopes
Volume	62
Issue number	4
Publication status	Published - Apr 2005

Keywords

17F
Fluoromethane
PET

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title = "Production of [17F]CH3F (t1/2 = 65 s), an improved PET tracer for rCBF measurement",

abstract = "Production of 17F (t1/2=65s) in the form of [17F] F2 has been achieved using both the 20Ne(p,α) 17F and 16O(d,n)17F reactions with 11 MeV protons and 6 MeV deuterons, respectively. Yields have proven suitable for subsequent radiosynthesis of the blood flow tracer, [17F]CH 3F (>60 mCi in saline), currently in use for fast repetition human studies of regional cerebral blood flow with positron emission tomography. Thick target yields of 15 mCi/μA for protons and 44 mCi/μA for deuterons have been measured for [17F]F2. {\textcopyright} 2004 Elsevier Ltd. All rights reserved.",

keywords = "17F, Fluoromethane, PET",

author = "Barnhart, {T. E.} and Converse, {A. K.} and Dabbs, {K. A.} and Schueller, {M. J.} and Stone, {C. K.} and Nickles, {R. J.} and Roberts, {A. D.}",

year = "2005",

month = apr,

language = "English",

volume = "62",

pages = "525--532",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier BV",

number = "4",

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TY - JOUR

T1 - Production of [17F]CH3F (t1/2 = 65 s), an improved PET tracer for rCBF measurement

AU - Barnhart, T. E.

AU - Converse, A. K.

AU - Dabbs, K. A.

AU - Schueller, M. J.

AU - Stone, C. K.

AU - Nickles, R. J.

AU - Roberts, A. D.

PY - 2005/4

Y1 - 2005/4

N2 - Production of 17F (t1/2=65s) in the form of [17F] F2 has been achieved using both the 20Ne(p,α) 17F and 16O(d,n)17F reactions with 11 MeV protons and 6 MeV deuterons, respectively. Yields have proven suitable for subsequent radiosynthesis of the blood flow tracer, [17F]CH 3F (>60 mCi in saline), currently in use for fast repetition human studies of regional cerebral blood flow with positron emission tomography. Thick target yields of 15 mCi/μA for protons and 44 mCi/μA for deuterons have been measured for [17F]F2. © 2004 Elsevier Ltd. All rights reserved.

AB - Production of 17F (t1/2=65s) in the form of [17F] F2 has been achieved using both the 20Ne(p,α) 17F and 16O(d,n)17F reactions with 11 MeV protons and 6 MeV deuterons, respectively. Yields have proven suitable for subsequent radiosynthesis of the blood flow tracer, [17F]CH 3F (>60 mCi in saline), currently in use for fast repetition human studies of regional cerebral blood flow with positron emission tomography. Thick target yields of 15 mCi/μA for protons and 44 mCi/μA for deuterons have been measured for [17F]F2. © 2004 Elsevier Ltd. All rights reserved.

KW - 17F

KW - Fluoromethane

KW - PET

M3 - Article

SN - 0969-8043

VL - 62

SP - 525

EP - 532

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

IS - 4

ER -

Production of [17F]CH3F (t1/2 = 65 s), an improved PET tracer for rCBF measurement

Abstract

Keywords

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