Production of Propane and Other Short-Chain Alkanes by Structure-Based Engineering of Ligand Specificity in Aldehyde-Deformylating Oxygenase

Basile Khara; Navya Menon; Colin Levy; David Mansell; Debasis Das; E. Neil G Marsh; David Leys; Nigel S. Scrutton

doi:10.1002/cbic.201300307

Production of Propane and Other Short-Chain Alkanes by Structure-Based Engineering of Ligand Specificity in Aldehyde-Deformylating Oxygenase

Basile Khara, Navya Menon, Colin Levy, David Mansell, Debasis Das, E. Neil G Marsh, David Leys, Nigel S. Scrutton

Manchester Institute of Biotechnology

Research output: Contribution to journal › Article › peer-review

Abstract

Biocatalytic propane production: structure-based engineering of aldehyde-deformylating oxygenase improves specificity for short- and medium-chain-length aldehydes and enhances the propane generation in whole-cell biotransformations. This presents new opportunities for developing biocatalytic modules for the production of volatile "drop-in" biofuels. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Original language	English
Pages (from-to)	1204-1208
Number of pages	4
Journal	ChemBioChem: a European journal of chemical biology
Volume	14
Issue number	10
DOIs	https://doi.org/10.1002/cbic.201300307
Publication status	Published - Jul 2013

Keywords

aldehyde decarbonylase
biofuels
decarbonylation
enzyme catalysis
specificity

Research Beacons, Institutes and Platforms

Manchester Institute of Biotechnology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/cbic.201300307

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title = "Production of Propane and Other Short-Chain Alkanes by Structure-Based Engineering of Ligand Specificity in Aldehyde-Deformylating Oxygenase",

abstract = "Biocatalytic propane production: structure-based engineering of aldehyde-deformylating oxygenase improves specificity for short- and medium-chain-length aldehydes and enhances the propane generation in whole-cell biotransformations. This presents new opportunities for developing biocatalytic modules for the production of volatile {"}drop-in{"} biofuels. {\textcopyright} 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

keywords = "aldehyde decarbonylase, biofuels, decarbonylation, enzyme catalysis, specificity",

author = "Basile Khara and Navya Menon and Colin Levy and David Mansell and Debasis Das and Marsh, {E. Neil G} and David Leys and Scrutton, {Nigel S.}",

year = "2013",

month = jul,

doi = "10.1002/cbic.201300307",

language = "English",

volume = "14",

pages = "1204--1208",

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T1 - Production of Propane and Other Short-Chain Alkanes by Structure-Based Engineering of Ligand Specificity in Aldehyde-Deformylating Oxygenase

AU - Khara, Basile

AU - Menon, Navya

AU - Levy, Colin

AU - Mansell, David

AU - Das, Debasis

AU - Marsh, E. Neil G

AU - Leys, David

AU - Scrutton, Nigel S.

PY - 2013/7

Y1 - 2013/7

N2 - Biocatalytic propane production: structure-based engineering of aldehyde-deformylating oxygenase improves specificity for short- and medium-chain-length aldehydes and enhances the propane generation in whole-cell biotransformations. This presents new opportunities for developing biocatalytic modules for the production of volatile "drop-in" biofuels. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

AB - Biocatalytic propane production: structure-based engineering of aldehyde-deformylating oxygenase improves specificity for short- and medium-chain-length aldehydes and enhances the propane generation in whole-cell biotransformations. This presents new opportunities for developing biocatalytic modules for the production of volatile "drop-in" biofuels. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KW - aldehyde decarbonylase

KW - biofuels

KW - decarbonylation

KW - enzyme catalysis

KW - specificity

U2 - 10.1002/cbic.201300307

DO - 10.1002/cbic.201300307

M3 - Article

SN - 1439-7633

VL - 14

SP - 1204

EP - 1208

JO - ChemBioChem: a European journal of chemical biology

JF - ChemBioChem: a European journal of chemical biology

IS - 10

ER -

Production of Propane and Other Short-Chain Alkanes by Structure-Based Engineering of Ligand Specificity in Aldehyde-Deformylating Oxygenase

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

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