Productive infection and cell-free transmission of human T-cell leukemia virus in a nonlymphoid cell line

P. Clapham; K. Nagy; R. Cheingsong-Popov; M. Exley; R. A. Weiss

doi:10.1126/science.6316502

Productive infection and cell-free transmission of human T-cell leukemia virus in a nonlymphoid cell line

P. Clapham
, K. Nagy
, R. Cheingsong-Popov
, M. Exley
, R. A. Weiss

Research output: Contribution to journal › Article › peer-review

Abstract

Human T-cell leukemia virus (HTLV), American PL isolate, was transmitted by cocultivation and by cell-free filtrates to a nonlymphoid human osteogenic sarcoma (HOS) cell line, designated HOS/PL, but not to nine other lines bearing receptors for HTLV. HOS and HOS/PL cells are not dependent on interleukin-2 and do not express interleukin-2 receptors that are recognized by antiTac monoclonal antibody. HTLV released by the Japanese MT2 cell line was also transmitted to HOS cells. The infected HOS cells release substantial titers of progeny HTLV which is antigenically indistinguishable from parental virus and is able to transform T cells.

Original language	English
Pages (from-to)	1125-1127
Number of pages	2
Journal	Science
Volume	222
Issue number	4628
DOIs	https://doi.org/10.1126/science.6316502
Publication status	Published - 1983

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1126/science.6316502

Cite this

@article{74cf3b28da1e496f8d4c8b5877fdb5f5,

title = "Productive infection and cell-free transmission of human T-cell leukemia virus in a nonlymphoid cell line",

abstract = "Human T-cell leukemia virus (HTLV), American PL isolate, was transmitted by cocultivation and by cell-free filtrates to a nonlymphoid human osteogenic sarcoma (HOS) cell line, designated HOS/PL, but not to nine other lines bearing receptors for HTLV. HOS and HOS/PL cells are not dependent on interleukin-2 and do not express interleukin-2 receptors that are recognized by antiTac monoclonal antibody. HTLV released by the Japanese MT2 cell line was also transmitted to HOS cells. The infected HOS cells release substantial titers of progeny HTLV which is antigenically indistinguishable from parental virus and is able to transform T cells.",

author = "P. Clapham and K. Nagy and R. Cheingsong-Popov and M. Exley and Weiss, \{R. A.\}",

year = "1983",

doi = "10.1126/science.6316502",

language = "English",

volume = "222",

pages = "1125--1127",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science (A A A S)",

number = "4628",

}

TY - JOUR

T1 - Productive infection and cell-free transmission of human T-cell leukemia virus in a nonlymphoid cell line

AU - Clapham, P.

AU - Nagy, K.

AU - Cheingsong-Popov, R.

AU - Exley, M.

AU - Weiss, R. A.

PY - 1983

Y1 - 1983

N2 - Human T-cell leukemia virus (HTLV), American PL isolate, was transmitted by cocultivation and by cell-free filtrates to a nonlymphoid human osteogenic sarcoma (HOS) cell line, designated HOS/PL, but not to nine other lines bearing receptors for HTLV. HOS and HOS/PL cells are not dependent on interleukin-2 and do not express interleukin-2 receptors that are recognized by antiTac monoclonal antibody. HTLV released by the Japanese MT2 cell line was also transmitted to HOS cells. The infected HOS cells release substantial titers of progeny HTLV which is antigenically indistinguishable from parental virus and is able to transform T cells.

AB - Human T-cell leukemia virus (HTLV), American PL isolate, was transmitted by cocultivation and by cell-free filtrates to a nonlymphoid human osteogenic sarcoma (HOS) cell line, designated HOS/PL, but not to nine other lines bearing receptors for HTLV. HOS and HOS/PL cells are not dependent on interleukin-2 and do not express interleukin-2 receptors that are recognized by antiTac monoclonal antibody. HTLV released by the Japanese MT2 cell line was also transmitted to HOS cells. The infected HOS cells release substantial titers of progeny HTLV which is antigenically indistinguishable from parental virus and is able to transform T cells.

U2 - 10.1126/science.6316502

DO - 10.1126/science.6316502

M3 - Article

C2 - 6316502

SN - 0036-8075

VL - 222

SP - 1125

EP - 1127

JO - Science

JF - Science

IS - 4628

ER -

Productive infection and cell-free transmission of human T-cell leukemia virus in a nonlymphoid cell line

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this