Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease

Abigail C. Lay; Van Du T. Tran; Viji Nair; Virginie Betin; Jennifer A. Hurcombe; Alexandra F. Barrington; Robert JP Pope; Frédéric Burdet; Florence Mehl; Dmytro Kryvokhyzha; Abrar Ahmad; Matthew C. Sinton; Marieangela C. Wilson; Rajasree Menon; Edgar Otto; Kate J. Heesom; Mark Ibberson; Helen C. Looker; Robert G. Nelson; Wenjun Ju; Matthias Kretzler; Simon C. Satchell; Maria F. Gomez; Wenjun Ju; Matthias Kretzler; Richard J. M. Coward

doi:10.1038/s41467-024-54089-1

Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease

Abigail C. Lay, Van Du T. Tran, Viji Nair, Virginie Betin, Jennifer A. Hurcombe, Alexandra F. Barrington, Robert JP Pope, Frédéric Burdet, Florence Mehl, Dmytro Kryvokhyzha, Abrar Ahmad, Matthew C. Sinton, Marieangela C. Wilson, Rajasree Menon, Edgar Otto, Kate J. Heesom, Mark Ibberson, Helen C. Looker, Robert G. Nelson, Wenjun JuMatthias Kretzler, Simon C. Satchell, Maria F. Gomez, Wenjun Ju, Matthias Kretzler, Richard J. M. Coward

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Nature Communications
DOIs	https://doi.org/10.1038/s41467-024-54089-1
Publication status	Published - 19 Nov 2024

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10.1038/s41467-024-54089-1

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Lay, A. C., Tran, V. D. T., Nair, V., Betin, V., Hurcombe, J. A., Barrington, A. F., Pope, R. JP., Burdet, F., Mehl, F., Kryvokhyzha, D., Ahmad, A., Sinton, M. C., Wilson, M. C., Menon, R., Otto, E., Heesom, K. J., Ibberson, M., Looker, H. C., Nelson, R. G., ... Coward, R. J. M. (2024). Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease. Nature Communications. https://doi.org/10.1038/s41467-024-54089-1

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title = "Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease",

author = "Lay, {Abigail C.} and Tran, {Van Du T.} and Viji Nair and Virginie Betin and Hurcombe, {Jennifer A.} and Barrington, {Alexandra F.} and Pope, {Robert JP} and Fr{\'e}d{\'e}ric Burdet and Florence Mehl and Dmytro Kryvokhyzha and Abrar Ahmad and Sinton, {Matthew C.} and Wilson, {Marieangela C.} and Rajasree Menon and Edgar Otto and Heesom, {Kate J.} and Mark Ibberson and Looker, {Helen C.} and Nelson, {Robert G.} and Wenjun Ju and Matthias Kretzler and Satchell, {Simon C.} and Gomez, {Maria F.} and Wenjun Ju and Matthias Kretzler and Coward, {Richard J. M.}",

year = "2024",

month = nov,

day = "19",

doi = "10.1038/s41467-024-54089-1",

language = "English",

journal = "Nature Communications",

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Lay, AC, Tran, VDT, Nair, V, Betin, V, Hurcombe, JA, Barrington, AF, Pope, RJP, Burdet, F, Mehl, F, Kryvokhyzha, D, Ahmad, A, Sinton, MC, Wilson, MC, Menon, R, Otto, E, Heesom, KJ, Ibberson, M, Looker, HC, Nelson, RG, Ju, W, Kretzler, M, Satchell, SC, Gomez, MF, Ju, W, Kretzler, M & Coward, RJM 2024, 'Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease', Nature Communications. https://doi.org/10.1038/s41467-024-54089-1

TY - JOUR

T1 - Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease

AU - Lay, Abigail C.

AU - Tran, Van Du T.

AU - Nair, Viji

AU - Betin, Virginie

AU - Hurcombe, Jennifer A.

AU - Barrington, Alexandra F.

AU - Pope, Robert JP

AU - Burdet, Frédéric

AU - Mehl, Florence

AU - Kryvokhyzha, Dmytro

AU - Ahmad, Abrar

AU - Sinton, Matthew C.

AU - Wilson, Marieangela C.

AU - Menon, Rajasree

AU - Otto, Edgar

AU - Heesom, Kate J.

AU - Ibberson, Mark

AU - Looker, Helen C.

AU - Nelson, Robert G.

AU - Ju, Wenjun

AU - Kretzler, Matthias

AU - Satchell, Simon C.

AU - Gomez, Maria F.

AU - Ju, Wenjun

AU - Kretzler, Matthias

AU - Coward, Richard J. M.

PY - 2024/11/19

Y1 - 2024/11/19

UR - https://doi.org/10.1038/s41467-024-54089-1

U2 - 10.1038/s41467-024-54089-1

DO - 10.1038/s41467-024-54089-1

M3 - Article

SN - 2041-1723

JO - Nature Communications

JF - Nature Communications

ER -

Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease

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