Prognosis of myasthenia gravis: A retrospective study of 380 patients

Vittorio Cosi; Alfredo Rumani; Maria Lombardi; Elda Raiola; Roberto Bergamaschi; Giovanni Piccolo; Antonietta Citterio; Carlo Berzuini

doi:10.1007/s004150050142

Prognosis of myasthenia gravis: A retrospective study of 380 patients

Vittorio Cosi, Alfredo Rumani, Maria Lombardi, Elda Raiola, Roberto Bergamaschi, Giovanni Piccolo, Antonietta Citterio, Carlo Berzuini

Research output: Contribution to journal › Article › peer-review

Abstract

The 9139 follow-up records of 438 myasthenia gravis (MG) patients were reviewed. Excluding those patients who were diagnosed 5 or more years after symptom onset (n = 37) and those who experienced only oculomotor symptoms throughout follow-up (n = 21), there were 380 patients. A survival analysis approach was used to assess the influence of prognostic factors on the following endpoints: (a) stable complete remission. (b) complete remission of at least 6 months and (c) pharmacological remission of at least 6 months. Early diagnosis was associated with a better prognosis with respect to all endpoints. Thymectomy also improved the prognosis but only for those patients without thymoma. Later MG onset was associated with a higher tendency to achieve pharmacological remission.

Original language	English
Pages (from-to)	548-555
Number of pages	7
Journal	Journal of Neurology
Volume	244
Issue number	9
DOIs	https://doi.org/10.1007/s004150050142
Publication status	Published - 1997

Keywords

Myasthenia gravis
Prognosis
Retrospective study

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10.1007/s004150050142

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title = "Prognosis of myasthenia gravis: A retrospective study of 380 patients",

abstract = "The 9139 follow-up records of 438 myasthenia gravis (MG) patients were reviewed. Excluding those patients who were diagnosed 5 or more years after symptom onset (n = 37) and those who experienced only oculomotor symptoms throughout follow-up (n = 21), there were 380 patients. A survival analysis approach was used to assess the influence of prognostic factors on the following endpoints: (a) stable complete remission. (b) complete remission of at least 6 months and (c) pharmacological remission of at least 6 months. Early diagnosis was associated with a better prognosis with respect to all endpoints. Thymectomy also improved the prognosis but only for those patients without thymoma. Later MG onset was associated with a higher tendency to achieve pharmacological remission.",

keywords = "Myasthenia gravis, Prognosis, Retrospective study",

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T1 - Prognosis of myasthenia gravis: A retrospective study of 380 patients

AU - Cosi, Vittorio

AU - Rumani, Alfredo

AU - Lombardi, Maria

AU - Raiola, Elda

AU - Bergamaschi, Roberto

AU - Piccolo, Giovanni

AU - Citterio, Antonietta

AU - Berzuini, Carlo

PY - 1997

Y1 - 1997

N2 - The 9139 follow-up records of 438 myasthenia gravis (MG) patients were reviewed. Excluding those patients who were diagnosed 5 or more years after symptom onset (n = 37) and those who experienced only oculomotor symptoms throughout follow-up (n = 21), there were 380 patients. A survival analysis approach was used to assess the influence of prognostic factors on the following endpoints: (a) stable complete remission. (b) complete remission of at least 6 months and (c) pharmacological remission of at least 6 months. Early diagnosis was associated with a better prognosis with respect to all endpoints. Thymectomy also improved the prognosis but only for those patients without thymoma. Later MG onset was associated with a higher tendency to achieve pharmacological remission.

AB - The 9139 follow-up records of 438 myasthenia gravis (MG) patients were reviewed. Excluding those patients who were diagnosed 5 or more years after symptom onset (n = 37) and those who experienced only oculomotor symptoms throughout follow-up (n = 21), there were 380 patients. A survival analysis approach was used to assess the influence of prognostic factors on the following endpoints: (a) stable complete remission. (b) complete remission of at least 6 months and (c) pharmacological remission of at least 6 months. Early diagnosis was associated with a better prognosis with respect to all endpoints. Thymectomy also improved the prognosis but only for those patients without thymoma. Later MG onset was associated with a higher tendency to achieve pharmacological remission.

KW - Myasthenia gravis

KW - Prognosis

KW - Retrospective study

U2 - 10.1007/s004150050142

DO - 10.1007/s004150050142

M3 - Article

SN - 0340-5354

VL - 244

SP - 548

EP - 555

JO - Journal of Neurology

JF - Journal of Neurology

IS - 9

ER -

Prognosis of myasthenia gravis: A retrospective study of 380 patients

Abstract

Keywords

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