Prognostic significance of low muscle volume in patients undergoing surgery for oesophageal cancer

Arfon Powell; Mubashir Mulla; Catherine Eley; Neil Patel; Tarig Abdelrahman; Paul Blake; Rachael Barlow; Damian Bailey; Wyn Griffith Lewis

doi:10.1016/j.clnesp.2020.09.016

Prognostic significance of low muscle volume in patients undergoing surgery for oesophageal cancer

Arfon Powell, Mubashir Mulla, Catherine Eley, Neil Patel, Tarig Abdelrahman, Paul Blake, Rachael Barlow, Damian Bailey, Wyn Griffith Lewis

Division of Diabetes, Endocrinology & Gastroenterology (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Background & aims: This study aimed to determine the prognostic significance of low muscle volume (LMV) Bioelectrical Impedance Analysis (BIA), defined skeletal muscle index (SMI, Kg/m² male ≤8.75, female ≤5.75) in patients undergoing potentially curative surgery for Oesophageal Cancer (OC).

Methods: A prospective study of 122 patients diagnosed with OC [median age 65 yr, 104 male, 65 neoadjuvant therapy] who underwent preoperative BIA (Maltron Bioscan 920). Primary outcome measure was Overall Survival (OS).

Results: LMV was identified in 11 (9.0%) of patients, which was associated with low lean muscle mass (27.3 vs. 31.1 kg, p = 0.012), low body fat (8.8 vs.19.3 kg, p < 0.001), and greater total body water (72.2 vs. 62.2%, p = 0.001), and more open & close laparotomies (36.4 vs. 8.1%, p = 0.012). Median and 5-year OS was 16 months and 18.2% in LMV patients, compared with 51 months and 52.4% in non-sarcopenic patients (p = 0.002). On multivariable analysis of pre-operative variables, only LMV (HR 2.75; 95% CI 1.33–5.66, p = 0.006) was associated with OS.

Conclusion: BIA is an important prognostic indicator in OC and focused pre-habilitation consequently has strong potential.

Original language	English
Pages (from-to)	220-225
Number of pages	6
Journal	Clinical Nutrition ESPEN
Volume	40
DOIs	https://doi.org/10.1016/j.clnesp.2020.09.016
Publication status	Published - Dec 2020

Keywords

oesophageal cancer
mobidity
low muscle volume
survival

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.clnesp.2020.09.016

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@article{8a20657128eb4a9cbe53af62dfdc79f2,

title = "Prognostic significance of low muscle volume in patients undergoing surgery for oesophageal cancer",

abstract = "Background & aims: This study aimed to determine the prognostic significance of low muscle volume (LMV) Bioelectrical Impedance Analysis (BIA), defined skeletal muscle index (SMI, Kg/m2 male ≤8.75, female ≤5.75) in patients undergoing potentially curative surgery for Oesophageal Cancer (OC).Methods: A prospective study of 122 patients diagnosed with OC [median age 65 yr, 104 male, 65 neoadjuvant therapy] who underwent preoperative BIA (Maltron Bioscan 920). Primary outcome measure was Overall Survival (OS).Results: LMV was identified in 11 (9.0%) of patients, which was associated with low lean muscle mass (27.3 vs. 31.1 kg, p = 0.012), low body fat (8.8 vs.19.3 kg, p < 0.001), and greater total body water (72.2 vs. 62.2%, p = 0.001), and more open & close laparotomies (36.4 vs. 8.1%, p = 0.012). Median and 5-year OS was 16 months and 18.2% in LMV patients, compared with 51 months and 52.4% in non-sarcopenic patients (p = 0.002). On multivariable analysis of pre-operative variables, only LMV (HR 2.75; 95% CI 1.33–5.66, p = 0.006) was associated with OS.Conclusion: BIA is an important prognostic indicator in OC and focused pre-habilitation consequently has strong potential.",

keywords = "oesophageal cancer, mobidity, low muscle volume, survival",

author = "Arfon Powell and Mubashir Mulla and Catherine Eley and Neil Patel and Tarig Abdelrahman and Paul Blake and Rachael Barlow and Damian Bailey and Lewis, {Wyn Griffith}",

year = "2020",

month = dec,

doi = "10.1016/j.clnesp.2020.09.016",

language = "English",

volume = "40",

pages = "220--225",

journal = "Clinical Nutrition ESPEN",

issn = "2405-4577",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Prognostic significance of low muscle volume in patients undergoing surgery for oesophageal cancer

AU - Powell, Arfon

AU - Mulla, Mubashir

AU - Eley, Catherine

AU - Patel, Neil

AU - Abdelrahman, Tarig

AU - Blake, Paul

AU - Barlow, Rachael

AU - Bailey, Damian

AU - Lewis, Wyn Griffith

PY - 2020/12

Y1 - 2020/12

N2 - Background & aims: This study aimed to determine the prognostic significance of low muscle volume (LMV) Bioelectrical Impedance Analysis (BIA), defined skeletal muscle index (SMI, Kg/m2 male ≤8.75, female ≤5.75) in patients undergoing potentially curative surgery for Oesophageal Cancer (OC).Methods: A prospective study of 122 patients diagnosed with OC [median age 65 yr, 104 male, 65 neoadjuvant therapy] who underwent preoperative BIA (Maltron Bioscan 920). Primary outcome measure was Overall Survival (OS).Results: LMV was identified in 11 (9.0%) of patients, which was associated with low lean muscle mass (27.3 vs. 31.1 kg, p = 0.012), low body fat (8.8 vs.19.3 kg, p < 0.001), and greater total body water (72.2 vs. 62.2%, p = 0.001), and more open & close laparotomies (36.4 vs. 8.1%, p = 0.012). Median and 5-year OS was 16 months and 18.2% in LMV patients, compared with 51 months and 52.4% in non-sarcopenic patients (p = 0.002). On multivariable analysis of pre-operative variables, only LMV (HR 2.75; 95% CI 1.33–5.66, p = 0.006) was associated with OS.Conclusion: BIA is an important prognostic indicator in OC and focused pre-habilitation consequently has strong potential.

AB - Background & aims: This study aimed to determine the prognostic significance of low muscle volume (LMV) Bioelectrical Impedance Analysis (BIA), defined skeletal muscle index (SMI, Kg/m2 male ≤8.75, female ≤5.75) in patients undergoing potentially curative surgery for Oesophageal Cancer (OC).Methods: A prospective study of 122 patients diagnosed with OC [median age 65 yr, 104 male, 65 neoadjuvant therapy] who underwent preoperative BIA (Maltron Bioscan 920). Primary outcome measure was Overall Survival (OS).Results: LMV was identified in 11 (9.0%) of patients, which was associated with low lean muscle mass (27.3 vs. 31.1 kg, p = 0.012), low body fat (8.8 vs.19.3 kg, p < 0.001), and greater total body water (72.2 vs. 62.2%, p = 0.001), and more open & close laparotomies (36.4 vs. 8.1%, p = 0.012). Median and 5-year OS was 16 months and 18.2% in LMV patients, compared with 51 months and 52.4% in non-sarcopenic patients (p = 0.002). On multivariable analysis of pre-operative variables, only LMV (HR 2.75; 95% CI 1.33–5.66, p = 0.006) was associated with OS.Conclusion: BIA is an important prognostic indicator in OC and focused pre-habilitation consequently has strong potential.

KW - oesophageal cancer

KW - mobidity

KW - low muscle volume

KW - survival

U2 - 10.1016/j.clnesp.2020.09.016

DO - 10.1016/j.clnesp.2020.09.016

M3 - Article

SN - 2405-4577

VL - 40

SP - 220

EP - 225

JO - Clinical Nutrition ESPEN

JF - Clinical Nutrition ESPEN

ER -

Prognostic significance of low muscle volume in patients undergoing surgery for oesophageal cancer

Abstract

Keywords

UN SDGs

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