Prognostic significance of low muscle volume in patients undergoing surgery for oesophageal cancer

Arfon Powell; Mubashir Mulla; Catherine Eley; Neil Patel; Tarig Abdelrahman; Paul Blake; Rachael Barlow; Damian Bailey; Wyn Griffith Lewis

doi:10.1016/j.clnesp.2020.09.016

Prognostic significance of low muscle volume in patients undergoing surgery for oesophageal cancer

Arfon Powell
, Mubashir Mulla
, Catherine Eley
, Neil Patel
, Tarig Abdelrahman
, Paul Blake
, Rachael Barlow
, Damian Bailey
, Wyn Griffith Lewis

Division of Diabetes, Endocrinology & Gastroenterology (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Background & aims: This study aimed to determine the prognostic significance of low muscle volume (LMV) Bioelectrical Impedance Analysis (BIA), defined skeletal muscle index (SMI, Kg/m² male ≤8.75, female ≤5.75) in patients undergoing potentially curative surgery for Oesophageal Cancer (OC).

Methods: A prospective study of 122 patients diagnosed with OC [median age 65 yr, 104 male, 65 neoadjuvant therapy] who underwent preoperative BIA (Maltron Bioscan 920). Primary outcome measure was Overall Survival (OS).

Results: LMV was identified in 11 (9.0%) of patients, which was associated with low lean muscle mass (27.3 vs. 31.1 kg, p = 0.012), low body fat (8.8 vs.19.3 kg, p < 0.001), and greater total body water (72.2 vs. 62.2%, p = 0.001), and more open & close laparotomies (36.4 vs. 8.1%, p = 0.012). Median and 5-year OS was 16 months and 18.2% in LMV patients, compared with 51 months and 52.4% in non-sarcopenic patients (p = 0.002). On multivariable analysis of pre-operative variables, only LMV (HR 2.75; 95% CI 1.33–5.66, p = 0.006) was associated with OS.

Conclusion: BIA is an important prognostic indicator in OC and focused pre-habilitation consequently has strong potential.

Original language	English
Pages (from-to)	220-225
Number of pages	6
Journal	Clinical Nutrition ESPEN
Volume	40
DOIs	https://doi.org/10.1016/j.clnesp.2020.09.016
Publication status	Published - Dec 2020

Keywords

oesophageal cancer
mobidity
low muscle volume
survival

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.clnesp.2020.09.016

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@article{8a20657128eb4a9cbe53af62dfdc79f2,

title = "Prognostic significance of low muscle volume in patients undergoing surgery for oesophageal cancer",

abstract = "Background \& aims: This study aimed to determine the prognostic significance of low muscle volume (LMV) Bioelectrical Impedance Analysis (BIA), defined skeletal muscle index (SMI, Kg/m2 male ≤8.75, female ≤5.75) in patients undergoing potentially curative surgery for Oesophageal Cancer (OC). Methods: A prospective study of 122 patients diagnosed with OC [median age 65 yr, 104 male, 65 neoadjuvant therapy] who underwent preoperative BIA (Maltron Bioscan 920). Primary outcome measure was Overall Survival (OS). Results: LMV was identified in 11 (9.0\%) of patients, which was associated with low lean muscle mass (27.3 vs. 31.1 kg, p = 0.012), low body fat (8.8 vs.19.3 kg, p < 0.001), and greater total body water (72.2 vs. 62.2\%, p = 0.001), and more open \& close laparotomies (36.4 vs. 8.1\%, p = 0.012). Median and 5-year OS was 16 months and 18.2\% in LMV patients, compared with 51 months and 52.4\% in non-sarcopenic patients (p = 0.002). On multivariable analysis of pre-operative variables, only LMV (HR 2.75; 95\% CI 1.33–5.66, p = 0.006) was associated with OS. Conclusion: BIA is an important prognostic indicator in OC and focused pre-habilitation consequently has strong potential.",

keywords = "oesophageal cancer, mobidity, low muscle volume, survival",

author = "Arfon Powell and Mubashir Mulla and Catherine Eley and Neil Patel and Tarig Abdelrahman and Paul Blake and Rachael Barlow and Damian Bailey and Lewis, \{Wyn Griffith\}",

year = "2020",

month = dec,

doi = "10.1016/j.clnesp.2020.09.016",

language = "English",

volume = "40",

pages = "220--225",

journal = "Clinical Nutrition ESPEN",

issn = "2405-4577",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Prognostic significance of low muscle volume in patients undergoing surgery for oesophageal cancer

AU - Powell, Arfon

AU - Mulla, Mubashir

AU - Eley, Catherine

AU - Patel, Neil

AU - Abdelrahman, Tarig

AU - Blake, Paul

AU - Barlow, Rachael

AU - Bailey, Damian

AU - Lewis, Wyn Griffith

PY - 2020/12

Y1 - 2020/12

N2 - Background & aims: This study aimed to determine the prognostic significance of low muscle volume (LMV) Bioelectrical Impedance Analysis (BIA), defined skeletal muscle index (SMI, Kg/m2 male ≤8.75, female ≤5.75) in patients undergoing potentially curative surgery for Oesophageal Cancer (OC). Methods: A prospective study of 122 patients diagnosed with OC [median age 65 yr, 104 male, 65 neoadjuvant therapy] who underwent preoperative BIA (Maltron Bioscan 920). Primary outcome measure was Overall Survival (OS). Results: LMV was identified in 11 (9.0%) of patients, which was associated with low lean muscle mass (27.3 vs. 31.1 kg, p = 0.012), low body fat (8.8 vs.19.3 kg, p < 0.001), and greater total body water (72.2 vs. 62.2%, p = 0.001), and more open & close laparotomies (36.4 vs. 8.1%, p = 0.012). Median and 5-year OS was 16 months and 18.2% in LMV patients, compared with 51 months and 52.4% in non-sarcopenic patients (p = 0.002). On multivariable analysis of pre-operative variables, only LMV (HR 2.75; 95% CI 1.33–5.66, p = 0.006) was associated with OS. Conclusion: BIA is an important prognostic indicator in OC and focused pre-habilitation consequently has strong potential.

AB - Background & aims: This study aimed to determine the prognostic significance of low muscle volume (LMV) Bioelectrical Impedance Analysis (BIA), defined skeletal muscle index (SMI, Kg/m2 male ≤8.75, female ≤5.75) in patients undergoing potentially curative surgery for Oesophageal Cancer (OC). Methods: A prospective study of 122 patients diagnosed with OC [median age 65 yr, 104 male, 65 neoadjuvant therapy] who underwent preoperative BIA (Maltron Bioscan 920). Primary outcome measure was Overall Survival (OS). Results: LMV was identified in 11 (9.0%) of patients, which was associated with low lean muscle mass (27.3 vs. 31.1 kg, p = 0.012), low body fat (8.8 vs.19.3 kg, p < 0.001), and greater total body water (72.2 vs. 62.2%, p = 0.001), and more open & close laparotomies (36.4 vs. 8.1%, p = 0.012). Median and 5-year OS was 16 months and 18.2% in LMV patients, compared with 51 months and 52.4% in non-sarcopenic patients (p = 0.002). On multivariable analysis of pre-operative variables, only LMV (HR 2.75; 95% CI 1.33–5.66, p = 0.006) was associated with OS. Conclusion: BIA is an important prognostic indicator in OC and focused pre-habilitation consequently has strong potential.

KW - oesophageal cancer

KW - mobidity

KW - low muscle volume

KW - survival

U2 - 10.1016/j.clnesp.2020.09.016

DO - 10.1016/j.clnesp.2020.09.016

M3 - Article

SN - 2405-4577

VL - 40

SP - 220

EP - 225

JO - Clinical Nutrition ESPEN

JF - Clinical Nutrition ESPEN

ER -

Prognostic significance of low muscle volume in patients undergoing surgery for oesophageal cancer

Abstract

Keywords

UN SDGs

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