Prognostic value of energy loss index in asymptomatic aortic stenosis

Edda Bahlmann, Eva Gerdts, Dana Cramariuc, Christa Gohlke-Baerwolf, Christoph A. Nienaber, Kristian Wachtell, Reinhard Seifert, John B. Chambers, Karl Heinz Kuck, Simon Ray

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background-: Aortic valve area index adjusted for pressure recovery (energy loss index [ELI]) has been suggested as a more accurate measure of aortic stenosis (AS) severity, but its prognostic value has not been determined in a prospective study. Methods and Results-: The relation between baseline ELI and rate of aortic valve events and combined total mortality and hospitalization for heart failure resulting from the progression of AS was assessed by multivariate Cox regression and reclassification analysis in 1563 patients with initial asymptomatic AS in the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study. During 4.3 years follow-up, a total of 498 aortic valve events and 181 combined total mortalities and hospitalizations for heart failure caused by the progression of AS occurred. In Cox regression analyses, 1-cm2/m 2 lower baseline ELI predicted a 2-fold higher risk both for aortic valve events and for combined total mortality and hospitalization for heart failure independently of baseline peak aortic jet velocity or mean aortic gradient and independently of aortic root size (all P
    Original languageEnglish
    Pages (from-to)1149-1156
    Number of pages7
    JournalCirculation
    Volume127
    Issue number10
    DOIs
    Publication statusPublished - 12 Mar 2013

    Keywords

    • aortic valve
    • aortic valve stenosis
    • cardiovascular system
    • energy loss index

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