Prognostic value of hypoxia-associated markers in advanced larynx and hypopharynx squamous cell carcinoma.

Jonathan M Bernstein; Timothy D Andrews; Nick J Slevin; Catharine M L West; Jarrod J Homer

doi:10.1002/lary.24933

Prognostic value of hypoxia-associated markers in advanced larynx and hypopharynx squamous cell carcinoma.

Jonathan M Bernstein, Timothy D Andrews, Nick J Slevin, Catharine M L West, Jarrod J Homer

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVES/HYPOTHESIS: To determine the prognostic value of hypoxia-associated markers carbonic anhydrase-9 (CA-9) and hypoxia-inducible factor-1α (HIF-1α) in advanced larynx and hypopharynx squamous cell carcinoma (SCCa) treated by organ preservation strategies. STUDY DESIGN: Retrospective cohort study. METHODS: Pretreatment CA-9 and HIF-1α expression, clinicopathologic data, and tumor volume were analyzed in a series of 114 patients with T3-4 SCCa larynx or hypopharynx treated by (chemo)radiation. RESULTS: Adverse prognostic factors for locoregional control were T4 classification (P = 0.008), and for disease-specific survival were CA-9 positivity (P = 0.039), T4 classification (P = 0.001), larger tumor volume (P = 0.004), N1-3 classification (P = 0.002), and pretreatment hemoglobin

Original language	English
Journal	The Laryngoscope
Volume	125
Issue number	1
DOIs	https://doi.org/10.1002/lary.24933
Publication status	Published - Jan 2015

Keywords

CA-9
HIF-1α
Head and neck squamous cell carcinoma
biomarker
hypopharynx
larynx
tumor hypoxia
tumor volume

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/lary.24933

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@article{5f3ef13aff9a4ff7a244a8772c0aebc1,

title = "Prognostic value of hypoxia-associated markers in advanced larynx and hypopharynx squamous cell carcinoma.",

abstract = "OBJECTIVES/HYPOTHESIS: To determine the prognostic value of hypoxia-associated markers carbonic anhydrase-9 (CA-9) and hypoxia-inducible factor-1α (HIF-1α) in advanced larynx and hypopharynx squamous cell carcinoma (SCCa) treated by organ preservation strategies. STUDY DESIGN: Retrospective cohort study. METHODS: Pretreatment CA-9 and HIF-1α expression, clinicopathologic data, and tumor volume were analyzed in a series of 114 patients with T3-4 SCCa larynx or hypopharynx treated by (chemo)radiation. RESULTS: Adverse prognostic factors for locoregional control were T4 classification (P = 0.008), and for disease-specific survival were CA-9 positivity (P = 0.039), T4 classification (P = 0.001), larger tumor volume (P = 0.004), N1-3 classification (P = 0.002), and pretreatment hemoglobin ",

keywords = "CA-9, HIF-1α, Head and neck squamous cell carcinoma, biomarker, hypopharynx, larynx, tumor hypoxia, tumor volume",

author = "Bernstein, {Jonathan M} and Andrews, {Timothy D} and Slevin, {Nick J} and West, {Catharine M L} and Homer, {Jarrod J}",

year = "2015",

month = jan,

doi = "10.1002/lary.24933",

language = "English",

volume = "125",

journal = "The Laryngoscope",

issn = "1531-4995",

publisher = "John Wiley & Sons Ltd",

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TY - JOUR

T1 - Prognostic value of hypoxia-associated markers in advanced larynx and hypopharynx squamous cell carcinoma.

AU - Bernstein, Jonathan M

AU - Andrews, Timothy D

AU - Slevin, Nick J

AU - West, Catharine M L

AU - Homer, Jarrod J

PY - 2015/1

Y1 - 2015/1

N2 - OBJECTIVES/HYPOTHESIS: To determine the prognostic value of hypoxia-associated markers carbonic anhydrase-9 (CA-9) and hypoxia-inducible factor-1α (HIF-1α) in advanced larynx and hypopharynx squamous cell carcinoma (SCCa) treated by organ preservation strategies. STUDY DESIGN: Retrospective cohort study. METHODS: Pretreatment CA-9 and HIF-1α expression, clinicopathologic data, and tumor volume were analyzed in a series of 114 patients with T3-4 SCCa larynx or hypopharynx treated by (chemo)radiation. RESULTS: Adverse prognostic factors for locoregional control were T4 classification (P = 0.008), and for disease-specific survival were CA-9 positivity (P = 0.039), T4 classification (P = 0.001), larger tumor volume (P = 0.004), N1-3 classification (P = 0.002), and pretreatment hemoglobin

AB - OBJECTIVES/HYPOTHESIS: To determine the prognostic value of hypoxia-associated markers carbonic anhydrase-9 (CA-9) and hypoxia-inducible factor-1α (HIF-1α) in advanced larynx and hypopharynx squamous cell carcinoma (SCCa) treated by organ preservation strategies. STUDY DESIGN: Retrospective cohort study. METHODS: Pretreatment CA-9 and HIF-1α expression, clinicopathologic data, and tumor volume were analyzed in a series of 114 patients with T3-4 SCCa larynx or hypopharynx treated by (chemo)radiation. RESULTS: Adverse prognostic factors for locoregional control were T4 classification (P = 0.008), and for disease-specific survival were CA-9 positivity (P = 0.039), T4 classification (P = 0.001), larger tumor volume (P = 0.004), N1-3 classification (P = 0.002), and pretreatment hemoglobin

KW - CA-9

KW - HIF-1α

KW - Head and neck squamous cell carcinoma

KW - biomarker

KW - hypopharynx

KW - larynx

KW - tumor hypoxia

KW - tumor volume

U2 - 10.1002/lary.24933

DO - 10.1002/lary.24933

M3 - Article

C2 - 25230150

SN - 1531-4995

VL - 125

JO - The Laryngoscope

JF - The Laryngoscope

IS - 1

ER -

Prognostic value of hypoxia-associated markers in advanced larynx and hypopharynx squamous cell carcinoma.

Abstract

Keywords

UN SDGs

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