Progress in defining the genetic contribution to type 2 diabetes susceptibility

Research output: Contribution to journalReview articlepeer-review

Abstract

Candidate gene, genome-wide association, exome array and sequencing studies have identified more than 140 loci associated with type 2 diabetes (T2D) susceptibility. In this review, progress in understanding the genetic architecture of T2D susceptibility across diverse populations and in localising potential causal variants for the disease through fine-mapping studies is discussed. The additional insights gained from these genetic studies into novel molecular mechanisms and pathophysiology underlying T2D susceptibility are described, and the prospects for future genomic investigations of the disease are considered.

Original languageEnglish
Pages (from-to)41-51
Number of pages11
JournalCurrent Opinion in Genetics and Development
Volume50
Early online date21 Feb 2018
DOIs
Publication statusPublished - 1 Jun 2018

Keywords

  • Diabetes Mellitus, Type 2/genetics
  • Genetic Loci
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Humans
  • Polymorphism, Single Nucleotide/genetics

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