Proline 4-hydroxylase:: Stereochemical course of the reaction

J.E. Baldwin; R.A. Field; C.C. Lawrence; K.D. Merritt; C.J. Schofield

doi:10.1016/S0040-4039(00)60161-2

Proline 4-hydroxylase: Stereochemical course of the reaction

J.E. Baldwin, R.A. Field, C.C. Lawrence, K.D. Merritt, C.J. Schofield

Manchester Institute of Biotechnology

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Abstract

The stereochemical course of the hydroxylation of (S)-proline by proline 4-hydroxylase from Streptomyces griseoviridus P8648 has been investigated using (2S, 4S)-[4-2H1]-proline and (2S, 4R)-[4-2H1]-proline and found to occur with retention of stereochemistry at C-4 of proline.
The hydroxylation of (S)-proline to (2S, 4R)-hydroxyproline by bacterial proline 4-hydroxylase proceeds with retention of stereochemistry at C-4.

Original language	Undefined
Pages (from-to)	7489-7492
Number of pages	4
Journal	Tetrahedron Letters
Volume	34
Issue number	46
DOIs	https://doi.org/10.1016/S0040-4039(00)60161-2
Publication status	Published - 1993

Research Beacons, Institutes and Platforms

Manchester Institute of Biotechnology

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10.1016/S0040-4039(00)60161-2

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title = "Proline 4-hydroxylase:: Stereochemical course of the reaction",

abstract = "The stereochemical course of the hydroxylation of (S)-proline by proline 4-hydroxylase from Streptomyces griseoviridus P8648 has been investigated using (2S, 4S)-[4-2H1]-proline and (2S, 4R)-[4-2H1]-proline and found to occur with retention of stereochemistry at C-4 of proline.The hydroxylation of (S)-proline to (2S, 4R)-hydroxyproline by bacterial proline 4-hydroxylase proceeds with retention of stereochemistry at C-4.",

author = "J.E. Baldwin and R.A. Field and C.C. Lawrence and K.D. Merritt and C.J. Schofield",

year = "1993",

doi = "10.1016/S0040-4039(00)60161-2",

language = "Undefined",

volume = "34",

pages = "7489--7492",

journal = "Tetrahedron Letters",

issn = "0040-4039",

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TY - JOUR

T1 - Proline 4-hydroxylase:

T2 - Stereochemical course of the reaction

AU - Baldwin, J.E.

AU - Field, R.A.

AU - Lawrence, C.C.

AU - Merritt, K.D.

AU - Schofield, C.J.

PY - 1993

Y1 - 1993

N2 - The stereochemical course of the hydroxylation of (S)-proline by proline 4-hydroxylase from Streptomyces griseoviridus P8648 has been investigated using (2S, 4S)-[4-2H1]-proline and (2S, 4R)-[4-2H1]-proline and found to occur with retention of stereochemistry at C-4 of proline.The hydroxylation of (S)-proline to (2S, 4R)-hydroxyproline by bacterial proline 4-hydroxylase proceeds with retention of stereochemistry at C-4.

AB - The stereochemical course of the hydroxylation of (S)-proline by proline 4-hydroxylase from Streptomyces griseoviridus P8648 has been investigated using (2S, 4S)-[4-2H1]-proline and (2S, 4R)-[4-2H1]-proline and found to occur with retention of stereochemistry at C-4 of proline.The hydroxylation of (S)-proline to (2S, 4R)-hydroxyproline by bacterial proline 4-hydroxylase proceeds with retention of stereochemistry at C-4.

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-0027376450&partnerID=MN8TOARS

U2 - 10.1016/S0040-4039(00)60161-2

DO - 10.1016/S0040-4039(00)60161-2

M3 - Article

SN - 0040-4039

VL - 34

SP - 7489

EP - 7492

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 46

ER -

Proline 4-hydroxylase: Stereochemical course of the reaction

Abstract

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