Prophylactic cranial irradiation in extensive small-cell lung cancer

Ben Slotman; Corinne Faivre-Finn; Gijs Kramer; Elaine Rankin; Michael Snee; Matthew Hatton; Pieter Postmus; Laurence Collette; Elena Musat; Suresh Senan

doi:10.1056/NEJMoa071780

Prophylactic cranial irradiation in extensive small-cell lung cancer

Ben Slotman, Corinne Faivre-Finn, Gijs Kramer, Elaine Rankin, Michael Snee, Matthew Hatton, Pieter Postmus, Laurence Collette, Elena Musat, Suresh Senan

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: We conducted a randomized trial of prophylactic cranial irradiation in patients with extensive small-cell lung cancer who had had a response to chemotherapy. METHODS: Patients between the ages of 18 and 75 years with extensive small-cell lung cancer were randomly assigned to undergo prophylactic cranial irradiation (irradiation group) or receive no further therapy (control group). The primary end point was the time to symptomatic brain metastases. Computed tomography or magnetic resonance imaging of the brain was performed when any predefined key symptom suggestive of brain metastases was present. RESULTS: The two groups (each with 143 patients) were well balanced regarding baseline characteristics. Patients in the irradiation group had a lower risk of symptomatic brain metastases (hazard ratio, 0.27; 95% confidence interval [CI], 0.16 to 0.44; P

Original language	English
Pages (from-to)	664-672
Number of pages	8
Journal	New England Journal Of Medicine
Volume	357
Issue number	7
DOIs	https://doi.org/10.1056/NEJMoa071780
Publication status	Published - 16 Aug 2007

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10.1056/NEJMoa071780

http://content.nejm.org/cgi/reprint/357/7/664.pdf

Establishing the evidence for treatment to improve outcomes in patients with lung cancer
Blackhall, F. (Participant), Faivre-Finn, C. (Participant), Lorigan, P. (Participant), (Participant) & (Participant)
Impact: Health impacts

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title = "Prophylactic cranial irradiation in extensive small-cell lung cancer",

abstract = "BACKGROUND: We conducted a randomized trial of prophylactic cranial irradiation in patients with extensive small-cell lung cancer who had had a response to chemotherapy. METHODS: Patients between the ages of 18 and 75 years with extensive small-cell lung cancer were randomly assigned to undergo prophylactic cranial irradiation (irradiation group) or receive no further therapy (control group). The primary end point was the time to symptomatic brain metastases. Computed tomography or magnetic resonance imaging of the brain was performed when any predefined key symptom suggestive of brain metastases was present. RESULTS: The two groups (each with 143 patients) were well balanced regarding baseline characteristics. Patients in the irradiation group had a lower risk of symptomatic brain metastases (hazard ratio, 0.27; 95% confidence interval [CI], 0.16 to 0.44; P",

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T1 - Prophylactic cranial irradiation in extensive small-cell lung cancer

AU - Slotman, Ben

AU - Faivre-Finn, Corinne

AU - Kramer, Gijs

AU - Rankin, Elaine

AU - Snee, Michael

AU - Hatton, Matthew

AU - Postmus, Pieter

AU - Collette, Laurence

AU - Musat, Elena

AU - Senan, Suresh

PY - 2007/8/16

Y1 - 2007/8/16

N2 - BACKGROUND: We conducted a randomized trial of prophylactic cranial irradiation in patients with extensive small-cell lung cancer who had had a response to chemotherapy. METHODS: Patients between the ages of 18 and 75 years with extensive small-cell lung cancer were randomly assigned to undergo prophylactic cranial irradiation (irradiation group) or receive no further therapy (control group). The primary end point was the time to symptomatic brain metastases. Computed tomography or magnetic resonance imaging of the brain was performed when any predefined key symptom suggestive of brain metastases was present. RESULTS: The two groups (each with 143 patients) were well balanced regarding baseline characteristics. Patients in the irradiation group had a lower risk of symptomatic brain metastases (hazard ratio, 0.27; 95% confidence interval [CI], 0.16 to 0.44; P

AB - BACKGROUND: We conducted a randomized trial of prophylactic cranial irradiation in patients with extensive small-cell lung cancer who had had a response to chemotherapy. METHODS: Patients between the ages of 18 and 75 years with extensive small-cell lung cancer were randomly assigned to undergo prophylactic cranial irradiation (irradiation group) or receive no further therapy (control group). The primary end point was the time to symptomatic brain metastases. Computed tomography or magnetic resonance imaging of the brain was performed when any predefined key symptom suggestive of brain metastases was present. RESULTS: The two groups (each with 143 patients) were well balanced regarding baseline characteristics. Patients in the irradiation group had a lower risk of symptomatic brain metastases (hazard ratio, 0.27; 95% confidence interval [CI], 0.16 to 0.44; P

U2 - 10.1056/NEJMoa071780

DO - 10.1056/NEJMoa071780

M3 - Article

SN - 1533-4406

VL - 357

SP - 664

EP - 672

JO - New England Journal Of Medicine

JF - New England Journal Of Medicine

IS - 7

ER -

Prophylactic cranial irradiation in extensive small-cell lung cancer

Abstract

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Establishing the evidence for treatment to improve outcomes in patients with lung cancer

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