Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus.

J W M van der Linden, M C Arendrup, A Warris, K Lagrou, H Pelloux, P M Hauser, E Chryssanthou, E Mellado, S E Kidd, A M Tortorano, E Dannaoui, P Gaustad, J W Baddley, A Uekötter, C Lass-Flörl, N Klimko, C B Moore, D W Denning, A C Pasqualotto, C KibblerS Arikan-Akdagli, D Andes, J Meletiadis, L Naumiuk, M Nucci, W J G Melchers, P E Verweij

    Research output: Contribution to journalArticlepeer-review


    To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.
    Original languageEnglish
    JournalEmerging infectious diseases
    Issue number6
    Publication statusPublished - Jun 2015


    • Aspergillus
    • antimicrobial resistance
    • aspergillosis
    • azole resistance
    • fungi
    • international
    • prevalence
    • surveillance


    Dive into the research topics of 'Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus.'. Together they form a unique fingerprint.

    Cite this