Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus.

J W M van der Linden; M C Arendrup; A Warris; K Lagrou; H Pelloux; P M Hauser; E Chryssanthou; E Mellado; S E Kidd; A M Tortorano; E Dannaoui; P Gaustad; J W Baddley; A Uekötter; C Lass-Flörl; N Klimko; C B Moore; D W Denning; A C Pasqualotto; C Kibbler; S Arikan-Akdagli; D Andes; J Meletiadis; L Naumiuk; M Nucci; W J G Melchers; P E Verweij

doi:10.3201/eid2106.140717

Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus.

J W M van der Linden, M C Arendrup, A Warris, K Lagrou, H Pelloux, P M Hauser, E Chryssanthou, E Mellado, S E Kidd, A M Tortorano, E Dannaoui, P Gaustad, J W Baddley, A Uekötter, C Lass-Flörl, N Klimko, C B Moore, D W Denning, A C Pasqualotto, C KibblerS Arikan-Akdagli, D Andes, J Meletiadis, L Naumiuk, M Nucci, W J G Melchers, P E Verweij

Research output: Contribution to journal › Article › peer-review

Abstract

To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.

Original language	English
Journal	Emerging infectious diseases
Volume	21
Issue number	6
DOIs	https://doi.org/10.3201/eid2106.140717
Publication status	Published - Jun 2015

Keywords

Aspergillus
antimicrobial resistance
aspergillosis
azole resistance
fungi
international
prevalence
surveillance

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10.3201/eid2106.140717

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van der Linden, J. W. M., Arendrup, M. C., Warris, A., Lagrou, K., Pelloux, H., Hauser, P. M., Chryssanthou, E., Mellado, E., Kidd, S. E., Tortorano, A. M., Dannaoui, E., Gaustad, P., Baddley, J. W., Uekötter, A., Lass-Flörl, C., Klimko, N., Moore, C. B., Denning, D. W., Pasqualotto, A. C., ... Verweij, P. E. (2015). Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus. Emerging infectious diseases, 21(6). https://doi.org/10.3201/eid2106.140717

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title = "Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus.",

abstract = "To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2\% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.",

keywords = "Aspergillus, antimicrobial resistance, aspergillosis, azole resistance, fungi, international, prevalence, surveillance",

author = "\{van der Linden\}, \{J W M\} and Arendrup, \{M C\} and A Warris and K Lagrou and H Pelloux and Hauser, \{P M\} and E Chryssanthou and E Mellado and Kidd, \{S E\} and Tortorano, \{A M\} and E Dannaoui and P Gaustad and Baddley, \{J W\} and A Uek{\"o}tter and C Lass-Fl{\"o}rl and N Klimko and Moore, \{C B\} and Denning, \{D W\} and Pasqualotto, \{A C\} and C Kibbler and S Arikan-Akdagli and D Andes and J Meletiadis and L Naumiuk and M Nucci and Melchers, \{W J G\} and Verweij, \{P E\}",

year = "2015",

month = jun,

doi = "10.3201/eid2106.140717",

language = "English",

volume = "21",

journal = "Emerging infectious diseases",

issn = "1080-6059",

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van der Linden, JWM, Arendrup, MC, Warris, A, Lagrou, K, Pelloux, H, Hauser, PM, Chryssanthou, E, Mellado, E, Kidd, SE, Tortorano, AM, Dannaoui, E, Gaustad, P, Baddley, JW, Uekötter, A, Lass-Flörl, C, Klimko, N, Moore, CB, Denning, DW, Pasqualotto, AC, Kibbler, C, Arikan-Akdagli, S, Andes, D, Meletiadis, J, Naumiuk, L, Nucci, M, Melchers, WJG & Verweij, PE 2015, 'Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus.', Emerging infectious diseases, vol. 21, no. 6. https://doi.org/10.3201/eid2106.140717

TY - JOUR

T1 - Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus.

AU - van der Linden, J W M

AU - Arendrup, M C

AU - Warris, A

AU - Lagrou, K

AU - Pelloux, H

AU - Hauser, P M

AU - Chryssanthou, E

AU - Mellado, E

AU - Kidd, S E

AU - Tortorano, A M

AU - Dannaoui, E

AU - Gaustad, P

AU - Baddley, J W

AU - Uekötter, A

AU - Lass-Flörl, C

AU - Klimko, N

AU - Moore, C B

AU - Denning, D W

AU - Pasqualotto, A C

AU - Kibbler, C

AU - Arikan-Akdagli, S

AU - Andes, D

AU - Meletiadis, J

AU - Naumiuk, L

AU - Nucci, M

AU - Melchers, W J G

AU - Verweij, P E

PY - 2015/6

Y1 - 2015/6

N2 - To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.

AB - To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.

KW - Aspergillus

KW - antimicrobial resistance

KW - aspergillosis

KW - azole resistance

KW - fungi

KW - international

KW - prevalence

KW - surveillance

U2 - 10.3201/eid2106.140717

DO - 10.3201/eid2106.140717

M3 - Article

C2 - 25988348

SN - 1080-6059

VL - 21

JO - Emerging infectious diseases

JF - Emerging infectious diseases

IS - 6

ER -

Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus.

Abstract

Keywords

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