OBJECTIVE: VIM-1-producing K. pneumoniae (VPKP) is an emerging pathogen causing life-threatening infections. This study was conducted to identify the factors associated with bloodstream infections (BSI) caused by VPkP and to evaluate the importance of VIM production on outcome. METHOD: A prospective observational study was conducted in three tertiary care hospitals located in Athens, Greece, from 2004 to 2006. Consecutive patients with K. pneumoniae BSI were identified and monitored until discharge or death. Pertinent information was abstracted in a predesigned form. Antimicrobial susceptibility testing was performed by Etest. Microbial characteristics, including MBL production, blaVIM gene carriage and chromosomal types were examined. The data were analyzed to assess for risk factors associated with VPkP BSIs and 14-day mortality. RESULTS: A total of 178 patients with Klebsiella pneumoniae BSIs were identified; 67 (37.6%) were infected with a VPkP and 111 with a non-VPkP. MICs of imipenem for VPkP varied from the susceptible range to high-level resistance; 19 isolates were resistant to imipenem and 48 susceptible, whereas none of the non-VPkP exhibited resistance to carbapenems. VPkP were invariably multi-drug resistant. Prior use of carbapenems (OR 4.14; 95% CI 1.75-9.81; P=0.001) and stay in an intensive care unit (ICU) (OR 9.32; 95% CI 3.91-22.20; P<0.01) were independently associated with VPkP BSIs. Overall, patients infected with a VPkP had mortality rates similar to those infected with a non-VPkP. MIC of imipenem >4 ìg/mL (OR 4.27; 95% CI 1.41-12.95; P=0.01), older age (OR 1.03; 95% CI 1.00-1.05; P=0.03) and rapidly fatal underlying disease (OR 3.15; 95% CI 1.23-8.04; P=0.016) were independently associated with 14-day mortality. CONCLUSIONS: VPKP have spread widely in Greece and cause life-threatening infections, mainly in ICU patients who have had prior exposure to carbapenems. VPKP BSIs are associated with high mortality rates when the infecting organism is resistant to carbapenems.
|Number of pages||10|
|Journal||Archives of Hellenic Medicine|
|Publication status||Published - 1 May 2009|