Prostaglandin E2, a postulated astrocyte-derived neurovascular coupling agent, constricts rather than dilates parenchymal arterioles

Mark Nelson; Fabrice Dabertrand; Rachael M. Hannah; Jessica M. Pearson; David C. Hill-Eubanks; Joseph E. Brayden; Mark T. Nelson

doi:10.1038/jcbfm.2013.9

Prostaglandin E2, a postulated astrocyte-derived neurovascular coupling agent, constricts rather than dilates parenchymal arterioles

Mark Nelson, Fabrice Dabertrand, Rachael M. Hannah, Jessica M. Pearson, David C. Hill-Eubanks, Joseph E. Brayden, Mark T. Nelson

Research output: Contribution to journal › Article › peer-review

Abstract

It has been proposed that prostaglandin E2 (PGE2) is released from astrocytic endfeet to dilate parenchymal arterioles through activation of prostanoid (EP 4) receptors during neurovascular coupling. However, the direct effects of PGE2 on isolated parenchymal arterioles have not been tested. Here, we examined the effects of PGE 2 on the diameter of isolated pressurized parenchymal arterioles from rat and mouse brain. Contrary to the prevailing assumption, we found that PGE2 (0.1, 1, and 5 μmol/L) constricted rather than dilated parenchymal arterioles. Vasoconstriction to PGE2 was prevented by inhibitors of EP 1 receptors. These results strongly argue against a direct role of PGE2 on arterioles during neurovascular coupling. © 2013 ISCBFM All rights reserved.

Original language	English
Pages (from-to)	479-482
Number of pages	3
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	33
Issue number	4
DOIs	https://doi.org/10.1038/jcbfm.2013.9
Publication status	Published - Apr 2013

Keywords

astrocytes
brain parenchymal arterioles
neurovascular coupling
prostaglandin E2

Access to Document

10.1038/jcbfm.2013.9

Cite this

@article{b46a50ed29374a47bc3abde92b9e3740,

title = "Prostaglandin E2, a postulated astrocyte-derived neurovascular coupling agent, constricts rather than dilates parenchymal arterioles",

abstract = "It has been proposed that prostaglandin E2 (PGE2) is released from astrocytic endfeet to dilate parenchymal arterioles through activation of prostanoid (EP 4) receptors during neurovascular coupling. However, the direct effects of PGE2 on isolated parenchymal arterioles have not been tested. Here, we examined the effects of PGE 2 on the diameter of isolated pressurized parenchymal arterioles from rat and mouse brain. Contrary to the prevailing assumption, we found that PGE2 (0.1, 1, and 5 μmol/L) constricted rather than dilated parenchymal arterioles. Vasoconstriction to PGE2 was prevented by inhibitors of EP 1 receptors. These results strongly argue against a direct role of PGE2 on arterioles during neurovascular coupling. {\textcopyright} 2013 ISCBFM All rights reserved.",

keywords = "astrocytes, brain parenchymal arterioles, neurovascular coupling, prostaglandin E2",

author = "Mark Nelson and Fabrice Dabertrand and Hannah, {Rachael M.} and Pearson, {Jessica M.} and Hill-Eubanks, {David C.} and Brayden, {Joseph E.} and Nelson, {Mark T.}",

note = "P01 HL095488, NHLBI NIH HHS, United StatesP01HL095488, NHLBI NIH HHS, United StatesR01HL44455, NHLBI NIH HHS, United StatesR01HL58231, NHLBI NIH HHS, United StatesR37DK053832, NIDDK NIH HHS, United StatesT32HL007647, NHLBI NIH HHS, United StatesT32HL0077944, NHLBI NIH HHS, United States",

year = "2013",

month = apr,

doi = "10.1038/jcbfm.2013.9",

language = "English",

volume = "33",

pages = "479--482",

journal = "Journal of Cerebral Blood Flow and Metabolism",

issn = "1559-7016",

publisher = "SAGE Publications Inc.",

number = "4",

}

TY - JOUR

T1 - Prostaglandin E2, a postulated astrocyte-derived neurovascular coupling agent, constricts rather than dilates parenchymal arterioles

AU - Nelson, Mark

AU - Dabertrand, Fabrice

AU - Hannah, Rachael M.

AU - Pearson, Jessica M.

AU - Hill-Eubanks, David C.

AU - Brayden, Joseph E.

AU - Nelson, Mark T.

N1 - P01 HL095488, NHLBI NIH HHS, United StatesP01HL095488, NHLBI NIH HHS, United StatesR01HL44455, NHLBI NIH HHS, United StatesR01HL58231, NHLBI NIH HHS, United StatesR37DK053832, NIDDK NIH HHS, United StatesT32HL007647, NHLBI NIH HHS, United StatesT32HL0077944, NHLBI NIH HHS, United States

PY - 2013/4

Y1 - 2013/4

N2 - It has been proposed that prostaglandin E2 (PGE2) is released from astrocytic endfeet to dilate parenchymal arterioles through activation of prostanoid (EP 4) receptors during neurovascular coupling. However, the direct effects of PGE2 on isolated parenchymal arterioles have not been tested. Here, we examined the effects of PGE 2 on the diameter of isolated pressurized parenchymal arterioles from rat and mouse brain. Contrary to the prevailing assumption, we found that PGE2 (0.1, 1, and 5 μmol/L) constricted rather than dilated parenchymal arterioles. Vasoconstriction to PGE2 was prevented by inhibitors of EP 1 receptors. These results strongly argue against a direct role of PGE2 on arterioles during neurovascular coupling. © 2013 ISCBFM All rights reserved.

AB - It has been proposed that prostaglandin E2 (PGE2) is released from astrocytic endfeet to dilate parenchymal arterioles through activation of prostanoid (EP 4) receptors during neurovascular coupling. However, the direct effects of PGE2 on isolated parenchymal arterioles have not been tested. Here, we examined the effects of PGE 2 on the diameter of isolated pressurized parenchymal arterioles from rat and mouse brain. Contrary to the prevailing assumption, we found that PGE2 (0.1, 1, and 5 μmol/L) constricted rather than dilated parenchymal arterioles. Vasoconstriction to PGE2 was prevented by inhibitors of EP 1 receptors. These results strongly argue against a direct role of PGE2 on arterioles during neurovascular coupling. © 2013 ISCBFM All rights reserved.

KW - astrocytes

KW - brain parenchymal arterioles

KW - neurovascular coupling

KW - prostaglandin E2

U2 - 10.1038/jcbfm.2013.9

DO - 10.1038/jcbfm.2013.9

M3 - Article

C2 - 23385200

SN - 1559-7016

VL - 33

SP - 479

EP - 482

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

IS - 4

ER -

Prostaglandin E2, a postulated astrocyte-derived neurovascular coupling agent, constricts rather than dilates parenchymal arterioles

Abstract

Keywords

Access to Document

Fingerprint

Cite this