Prostaglandin production by melanocytic cells and the effect of α-melanocyte stimulating hormone

Anna Nicolaou, Sian E. Estdale, Marina Tsatmali, Daniel Pascual Herrero, Anthony J. Thody

    Research output: Contribution to journalArticlepeer-review


    Prostaglandins are potent mediators of the inflammatory response and are also involved in cancer development. In this study, we show that human melanocytes and FM55 melanoma cells express cyclooxygenase-1 and -2 (COX-1 and -2) and thus have the capability to produce prostaglandins. The FM55 cells produced predominantly PGE2 and PGF2α, whereas the HaCaT keratinocyte cell line produced mainly PGE2. The anti-inflammatory peptide, α-melanocyte stimulating hormone (α-MSH), reduced prostaglandin production in FM55 and HaCaT cells and reversed the effect of the pro-inflammatory cytokine TNF-α in the former. These results indicate that melanocytes produce prostaglandins and that α-MSH, by inhibiting this response, may play an important role in regulating inflammatory responses in the skin. © 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
    Original languageEnglish
    Pages (from-to)223-226
    Number of pages3
    JournalFEBS Letters
    Issue number1-3
    Publication statusPublished - 16 Jul 2004


    • α-Melanocyte stimulating hormone
    • α-MSH, α-melanocyte stimulating hormone
    • COX, cyclooxygenase
    • Cyclooxygenase
    • FM55
    • HaCaT
    • Melanocytic cell
    • Prostaglandin


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