Prostaglandin production by melanocytic cells and the effect of α-melanocyte stimulating hormone

Anna Nicolaou, Sian E. Estdale, Marina Tsatmali, Daniel Pascual Herrero, Anthony J. Thody

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Prostaglandins are potent mediators of the inflammatory response and are also involved in cancer development. In this study, we show that human melanocytes and FM55 melanoma cells express cyclooxygenase-1 and -2 (COX-1 and -2) and thus have the capability to produce prostaglandins. The FM55 cells produced predominantly PGE2 and PGF2α, whereas the HaCaT keratinocyte cell line produced mainly PGE2. The anti-inflammatory peptide, α-melanocyte stimulating hormone (α-MSH), reduced prostaglandin production in FM55 and HaCaT cells and reversed the effect of the pro-inflammatory cytokine TNF-α in the former. These results indicate that melanocytes produce prostaglandins and that α-MSH, by inhibiting this response, may play an important role in regulating inflammatory responses in the skin. © 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
    Original languageEnglish
    Pages (from-to)223-226
    Number of pages3
    JournalFEBS Letters
    Volume570
    Issue number1-3
    DOIs
    Publication statusPublished - 16 Jul 2004

    Keywords

    • α-Melanocyte stimulating hormone
    • α-MSH, α-melanocyte stimulating hormone
    • COX, cyclooxygenase
    • Cyclooxygenase
    • FM55
    • HaCaT
    • Melanocytic cell
    • Prostaglandin

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