Protection against chemotherapy-induced alopecia: Targeting ATP-binding cassette transporters in the hair follicle?

Iain S. Haslam, Aaron Pitre, John D. Schuetz, Ralf Paus

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Currently, efficacious treatments for chemotherapy-induced alopecia (hair loss) are lacking, and incidences of permanent hair loss following high-dose chemotherapy are on the increase. In this article, we describe mechanisms by which the pharmacological defense status of the hair follicle might be enhanced, thereby reducing the accumulation of cytotoxic cancer drugs and preventing or reducing hair loss and damage. We believe this could be achieved via the selective increase in ATP-binding cassette (ABC) transporter expression within the hair follicle epithelium, following application of topical agonists for regulatory nuclear receptors. Clinical application would require the development of hair follicle-targeted formulations, potentially utilizing nanoparticle technology. This novel approach has the potential to yield entirely new therapeutic options for the treatment and management of chemotherapy-induced alopecia, providing significant psychological and physical benefit to cancer patients. © 2013 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)599-604
    Number of pages5
    JournalTrends in pharmacological sciences
    Volume34
    Issue number11
    DOIs
    Publication statusPublished - Nov 2013

    Keywords

    • ATP-dependent transporters and drug resistance
    • nuclear receptors
    • structure and function of ABC transporters
    • xenobiotic defense

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