Protein digestibility and relevance to allergenicity

Gary Bannon; Tong Jen Fu; Ian Kimber; Dennis M. Hinton

doi:10.1289/ehp.5812

Protein digestibility and relevance to allergenicity

Gary Bannon, Tong Jen Fu, Ian Kimber, Dennis M. Hinton

Research output: Contribution to journal › Article › peer-review

Abstract

In January 2001 a Joint Food and Agriculture Organization of the United Nations/World Health Organization Expert Consultation Committee on Allergenicity of Foods Derived from Biotechnology published a report outlining in detail an approach for assessing the allergenic potential of novel proteins. One component of this decision tree is a determination of whether the protein of interest is resistant to proteolytic digestion. Although these in vitro methodologies have been useful, the correlation between resistance to proteolysis and allergenic activity is not absolute. Two views and highlights of supporting research regarding the relationship of resistance to digestion and allergenicity are presented in this article.

Original language	English
Pages (from-to)	1122-1124
Number of pages	2
Journal	Environmental Health Perspectives
Volume	111
Issue number	8
DOIs	https://doi.org/10.1289/ehp.5812
Publication status	Published - 1 Aug 2003

Keywords

Allergenicity
Protein stability
Protein structure
Proteolytic digestion
Safety assessment
Sequence homology
Simulated gastric fluid

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10.1289/ehp.5812

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title = "Protein digestibility and relevance to allergenicity",

abstract = "In January 2001 a Joint Food and Agriculture Organization of the United Nations/World Health Organization Expert Consultation Committee on Allergenicity of Foods Derived from Biotechnology published a report outlining in detail an approach for assessing the allergenic potential of novel proteins. One component of this decision tree is a determination of whether the protein of interest is resistant to proteolytic digestion. Although these in vitro methodologies have been useful, the correlation between resistance to proteolysis and allergenic activity is not absolute. Two views and highlights of supporting research regarding the relationship of resistance to digestion and allergenicity are presented in this article.",

keywords = "Allergenicity, Protein stability, Protein structure, Proteolytic digestion, Safety assessment, Sequence homology, Simulated gastric fluid",

author = "Gary Bannon and Fu, {Tong Jen} and Ian Kimber and Hinton, {Dennis M.}",

year = "2003",

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doi = "10.1289/ehp.5812",

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AU - Fu, Tong Jen

AU - Kimber, Ian

AU - Hinton, Dennis M.

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AB - In January 2001 a Joint Food and Agriculture Organization of the United Nations/World Health Organization Expert Consultation Committee on Allergenicity of Foods Derived from Biotechnology published a report outlining in detail an approach for assessing the allergenic potential of novel proteins. One component of this decision tree is a determination of whether the protein of interest is resistant to proteolytic digestion. Although these in vitro methodologies have been useful, the correlation between resistance to proteolysis and allergenic activity is not absolute. Two views and highlights of supporting research regarding the relationship of resistance to digestion and allergenicity are presented in this article.

KW - Allergenicity

KW - Protein stability

KW - Protein structure

KW - Proteolytic digestion

KW - Safety assessment

KW - Sequence homology

KW - Simulated gastric fluid

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VL - 111

SP - 1122

EP - 1124

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

IS - 8

ER -

Protein digestibility and relevance to allergenicity

Abstract

Keywords

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