Protein expression levels of carcinoembryonic antigen (CEA) in Danish ovarian cancer patients: From the Danish 'MALOVA'ovarian cancer study

Estrid V S Høgdall; Lise Christensen; Susanne K. Kjaer; Jan Blaakaer; Ib Jarle Christensen; Simon Gayther; Ian J. Jacobs; Claus K. Høgdall

doi:10.1080/00313020802197889

Protein expression levels of carcinoembryonic antigen (CEA) in Danish ovarian cancer patients: From the Danish 'MALOVA'ovarian cancer study

Estrid V S Høgdall, Lise Christensen, Susanne K. Kjaer, Jan Blaakaer, Ib Jarle Christensen, Simon Gayther, Ian J. Jacobs, Claus K. Høgdall

Research output: Contribution to journal › Article › peer-review

Abstract

Aims: To determine the variation in expression of carcinoembryonic antigen (CEA) in 760 epithelial ovarian tumours from Denmark, and to correlate expression with clinicopathological parameters and prognosis for the disease. Methods: Using tissue arrays (TA), we analysed CEA expression in tissues from 189 women diagnosed with low malignant potential ovarian tumours (LMP, borderline ovarian tumours) and 571 women diagnosed with ovarian cancer (OC). Results: Using 30% as the cut-off level for CEA over-expression, 18% of LMPs and 4% of OCs were positive. A higher proportion of mucinous tumours were positive compared with other histological subtypes (p

Original language	English
Pages (from-to)	487-492
Number of pages	5
Journal	Pathology
Volume	40
Issue number	5
DOIs	https://doi.org/10.1080/00313020802197889
Publication status	Published - Aug 2008

Keywords

Carcinoembryonic antigen
Immunohistochemistry
Ovarian cancer
Prognosis
Tissue array

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/00313020802197889

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title = "Protein expression levels of carcinoembryonic antigen (CEA) in Danish ovarian cancer patients: From the Danish 'MALOVA'ovarian cancer study",

abstract = "Aims: To determine the variation in expression of carcinoembryonic antigen (CEA) in 760 epithelial ovarian tumours from Denmark, and to correlate expression with clinicopathological parameters and prognosis for the disease. Methods: Using tissue arrays (TA), we analysed CEA expression in tissues from 189 women diagnosed with low malignant potential ovarian tumours (LMP, borderline ovarian tumours) and 571 women diagnosed with ovarian cancer (OC). Results: Using 30% as the cut-off level for CEA over-expression, 18% of LMPs and 4% of OCs were positive. A higher proportion of mucinous tumours were positive compared with other histological subtypes (p",

keywords = "Carcinoembryonic antigen, Immunohistochemistry, Ovarian cancer, Prognosis, Tissue array",

author = "H{\o}gdall, {Estrid V S} and Lise Christensen and Kjaer, {Susanne K.} and Jan Blaakaer and {Jarle Christensen}, Ib and Simon Gayther and Jacobs, {Ian J.} and H{\o}gdall, {Claus K.}",

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doi = "10.1080/00313020802197889",

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T1 - Protein expression levels of carcinoembryonic antigen (CEA) in Danish ovarian cancer patients: From the Danish 'MALOVA'ovarian cancer study

AU - Høgdall, Estrid V S

AU - Christensen, Lise

AU - Kjaer, Susanne K.

AU - Blaakaer, Jan

AU - Jarle Christensen, Ib

AU - Gayther, Simon

AU - Jacobs, Ian J.

AU - Høgdall, Claus K.

N1 - R01 CA 61107, NCI NIH HHS, United States

PY - 2008/8

Y1 - 2008/8

N2 - Aims: To determine the variation in expression of carcinoembryonic antigen (CEA) in 760 epithelial ovarian tumours from Denmark, and to correlate expression with clinicopathological parameters and prognosis for the disease. Methods: Using tissue arrays (TA), we analysed CEA expression in tissues from 189 women diagnosed with low malignant potential ovarian tumours (LMP, borderline ovarian tumours) and 571 women diagnosed with ovarian cancer (OC). Results: Using 30% as the cut-off level for CEA over-expression, 18% of LMPs and 4% of OCs were positive. A higher proportion of mucinous tumours were positive compared with other histological subtypes (p

AB - Aims: To determine the variation in expression of carcinoembryonic antigen (CEA) in 760 epithelial ovarian tumours from Denmark, and to correlate expression with clinicopathological parameters and prognosis for the disease. Methods: Using tissue arrays (TA), we analysed CEA expression in tissues from 189 women diagnosed with low malignant potential ovarian tumours (LMP, borderline ovarian tumours) and 571 women diagnosed with ovarian cancer (OC). Results: Using 30% as the cut-off level for CEA over-expression, 18% of LMPs and 4% of OCs were positive. A higher proportion of mucinous tumours were positive compared with other histological subtypes (p

KW - Carcinoembryonic antigen

KW - Immunohistochemistry

KW - Ovarian cancer

KW - Prognosis

KW - Tissue array

U2 - 10.1080/00313020802197889

DO - 10.1080/00313020802197889

M3 - Article

C2 - 18604735

SN - 0031-3025

VL - 40

SP - 487

EP - 492

JO - Pathology

JF - Pathology

IS - 5

ER -

Protein expression levels of carcinoembryonic antigen (CEA) in Danish ovarian cancer patients: From the Danish 'MALOVA'ovarian cancer study

Abstract

Keywords

UN SDGs

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