TY - JOUR
T1 - Protein surface recognition and proteomimetics: Mimics of protein surface structure and function
AU - Kostarelos, Kostas
AU - Fletcher, Steven
AU - Hamilton, Andrew D.
N1 - Times Cited: 507 3 519
PY - 2005/12
Y1 - 2005/12
N2 - Due to their key roles in a number of biological processes, protein-protein interactions are attractive and important targets, typically involving areas greater than 6 nm2. The disruption of such interactions remains a challenging feat but, in recent years, there has been considerable progress in the design of proteomimetics: molecules that mimic the structure and function of extended regions of protein surfaces. In particular, porphyrins, calixarenes, α-helical mimetics and small molecules have successfully modulated significant protein-protein interactions, including those involved in cancer and HIV. © 2005 Elsevier Ltd. All rights reserved.
AB - Due to their key roles in a number of biological processes, protein-protein interactions are attractive and important targets, typically involving areas greater than 6 nm2. The disruption of such interactions remains a challenging feat but, in recent years, there has been considerable progress in the design of proteomimetics: molecules that mimic the structure and function of extended regions of protein surfaces. In particular, porphyrins, calixarenes, α-helical mimetics and small molecules have successfully modulated significant protein-protein interactions, including those involved in cancer and HIV. © 2005 Elsevier Ltd. All rights reserved.
U2 - 10.1016/j.cbpa.2005.10.006
DO - 10.1016/j.cbpa.2005.10.006
M3 - Article
SN - 1879-0402
VL - 9
SP - 632
EP - 638
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
IS - 6
ER -
