Proteins interacting with nicotinic acetylcholine receptors: Expanding functional and therapeutic horizons

Andrew K. Jones, Steven D. Buckingham, David B. Sattelle

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that carry out the fast actions of the neurotransmitter acetylcholine (ACh). Over the past 30 years, it has become clear that the activity of nAChRs is dependent on their interaction with a host of proteins, and the number of these that have been identified has increased considerably with recent large-scale proteomic analyses. This review focuses on these interacting proteins, discussing how they regulate a wide range of functions including receptor assembly, and trafficking to and from the cell surface, as well as how they directly modulate functional characteristics such as sensitivity and the degree of response to ACh. Mutations giving rise to disease states highlight the importance of these interacting proteins. Here, we consider their potential as future therapeutic targets for treating diseases associated with altered nAChR function. © 2010 Elsevier Ltd.
    Original languageEnglish
    Pages (from-to)455-462
    Number of pages7
    JournalTrends in pharmacological sciences
    Volume31
    Issue number10
    DOIs
    Publication statusPublished - Oct 2010

    Fingerprint

    Dive into the research topics of 'Proteins interacting with nicotinic acetylcholine receptors: Expanding functional and therapeutic horizons'. Together they form a unique fingerprint.

    Cite this