Proteomics of the human malaria parasite Plasmodium falciparum

Paul F G Sims, John E. Hyde

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The lethal species of malaria parasite, Plasmodium falciparum, continues to exact a huge toll of mortality and morbidity, particularly in sub-Saharan Africa. Completion of the genome sequence of this organism and advances in proteomics and mass spectrometry have opened up unprecedented opportunities for understanding the complex biology of this parasite and how it responds to drug challenge and other interventions. This review describes recent progress that has been made in applying proteomics technology to this important pathogen and provides a look forward to likely future developments. © 2006 Future Drugs Ltd.
    Original languageEnglish
    Pages (from-to)87-95
    Number of pages8
    JournalExpert review of proteomics
    Volume3
    Issue number1
    DOIs
    Publication statusPublished - 2006

    Keywords

    • Cell cycle
    • Drug challenge
    • Mass spectrometry
    • Metabolic labeling
    • Post-translational modifications
    • Quantitative proteomics
    • Subproteome analysis

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