Proton Beam Therapy - the Challenges of Delivering High-quality Evidence of Clinical Benefit

National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad) Proton Beam Clinical Trial Strategy Group; Karen Kirkby

doi:10.1016/j.clon.2018.02.031

Proton Beam Therapy - the Challenges of Delivering High-quality Evidence of Clinical Benefit

National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad) Proton Beam Clinical Trial Strategy Group, Karen Kirkby

Division of Cancer Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

The use of proton beam therapy (PBT) offers the opportunity to improve greater conformality of radiotherapy treatment delivery in some patients. However, it is associated with a high capital cost and the need to build new dedicated facilities. We discuss how the global radiotherapy community can respond to the challenge of producing high-quality evidence of clinical benefit from PBT in adult patients. In the UK, the National Cancer Research Institute-funded Clinical and Radiotherapy Translational group has established the PBT Clinical Trial Strategy Group. An eight-point framework is described that can assist the development and delivery of high-quality clinical trials.

Original language	English
Pages (from-to)	280-284
Number of pages	5
Journal	Clinical oncology (Royal College of Radiologists (Great Britain))
Volume	30
Issue number	5
Early online date	15 Mar 2018
DOIs	https://doi.org/10.1016/j.clon.2018.02.031
Publication status	Published - May 2018

Keywords

Journal Article

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.clon.2018.02.031

Grand Challenge Network in Network+ in Proton Therapy.
Kirkby, K. & Taylor, M.
1/05/16 → 31/10/21
Project: Research
Global Challenge Network + in Advanced Radiotherapy.
Kirkby, K., Illidge, T., Kirkby, N., Mackay, R., Merchant, M. & Owen, H.
1/07/15 → 30/06/21
Project: Research

Establishing the UK’s first high-energy proton therapy service at the Christie Hospital Manchester and University College London Hospital.
Hywel Owen (Participant), Robert Appleby (Participant), Ranald Mackay (Participant), Karen Kirkby (Participant) & Roger Barlow (Participant)
Impact: Health and wellbeing, Economic, Technological

Cite this

National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad) Proton Beam Clinical Trial Strategy Group, & Kirkby, K. (2018). Proton Beam Therapy - the Challenges of Delivering High-quality Evidence of Clinical Benefit. Clinical oncology (Royal College of Radiologists (Great Britain)), 30(5), 280-284. https://doi.org/10.1016/j.clon.2018.02.031

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language = "English",

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National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad) Proton Beam Clinical Trial Strategy Group & Kirkby, K 2018, 'Proton Beam Therapy - the Challenges of Delivering High-quality Evidence of Clinical Benefit', Clinical oncology (Royal College of Radiologists (Great Britain)), vol. 30, no. 5, pp. 280-284. https://doi.org/10.1016/j.clon.2018.02.031

Proton Beam Therapy - the Challenges of Delivering High-quality Evidence of Clinical Benefit. / National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad) Proton Beam Clinical Trial Strategy Group ; Kirkby, Karen.

In: Clinical oncology (Royal College of Radiologists (Great Britain)), Vol. 30, No. 5, 05.2018, p. 280-284.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Proton Beam Therapy - the Challenges of Delivering High-quality Evidence of Clinical Benefit

AU - National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad) Proton Beam Clinical Trial Strategy Group

AU - Burnet, Neil

AU - Kirkby, Karen

PY - 2018/5

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N2 - The use of proton beam therapy (PBT) offers the opportunity to improve greater conformality of radiotherapy treatment delivery in some patients. However, it is associated with a high capital cost and the need to build new dedicated facilities. We discuss how the global radiotherapy community can respond to the challenge of producing high-quality evidence of clinical benefit from PBT in adult patients. In the UK, the National Cancer Research Institute-funded Clinical and Radiotherapy Translational group has established the PBT Clinical Trial Strategy Group. An eight-point framework is described that can assist the development and delivery of high-quality clinical trials.

AB - The use of proton beam therapy (PBT) offers the opportunity to improve greater conformality of radiotherapy treatment delivery in some patients. However, it is associated with a high capital cost and the need to build new dedicated facilities. We discuss how the global radiotherapy community can respond to the challenge of producing high-quality evidence of clinical benefit from PBT in adult patients. In the UK, the National Cancer Research Institute-funded Clinical and Radiotherapy Translational group has established the PBT Clinical Trial Strategy Group. An eight-point framework is described that can assist the development and delivery of high-quality clinical trials.

KW - Journal Article

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DO - 10.1016/j.clon.2018.02.031

M3 - Article

C2 - 29551566

VL - 30

SP - 280

EP - 284

JO - Clinical Oncology

JF - Clinical Oncology

SN - 0936-6555

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ER -

National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad) Proton Beam Clinical Trial Strategy Group, Kirkby K. Proton Beam Therapy - the Challenges of Delivering High-quality Evidence of Clinical Benefit. Clinical oncology (Royal College of Radiologists (Great Britain)). 2018 May;30(5):280-284. Epub 2018 Mar 15. doi: 10.1016/j.clon.2018.02.031

Proton Beam Therapy - the Challenges of Delivering High-quality Evidence of Clinical Benefit

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

Access to Document

Fingerprint

Projects

Grand Challenge Network in Network+ in Proton Therapy.

Global Challenge Network + in Advanced Radiotherapy.

Impacts

Establishing the UK’s first high-energy proton therapy service at the Christie Hospital Manchester and University College London Hospital.

Cite this