Psychiatric disorder, irritable bowel syndrome, and extra-intestinal symptoms in a population-based sample of twins

Francis Creed; Anthony J. Lembo; Mohammed Zaman; Robert F. Krueger; Barbara M. Tomenson; Francis H. Creed

doi:10.1038/ajg.2009.23

Psychiatric disorder, irritable bowel syndrome, and extra-intestinal symptoms in a population-based sample of twins

Francis Creed, Anthony J. Lembo, Mohammed Zaman, Robert F. Krueger, Barbara M. Tomenson, Francis H. Creed

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVES: To determine, in a population-based sample of twin pairs, if extra-intestinal symptoms (EIS) are closely associated with both irritable bowel syndrome (IBS) and psychiatric disorders and whether such associations are explained on a genetic basis. METHODS: A random sample of twins between the ages of 44 and 64 years enrolled in the Minnesota Twins Registry completed the Modified Mayo Clinic Bowel Disease Questionnaire, a questionnaire on extra-intestinal symptoms, and the Psychiatric Diagnostic Screening Questionnaire. RESULTS: Of the 3,048 participants (51% response rate), 371 (12.2%) fulfilled Rome II criteria for IBS; 61 (16.4%) had a psychiatric disorder compared with 7.6% (n=204) of those without IBS (P

Original language	English
Pages (from-to)	686-694
Number of pages	8
Journal	American Journal Of Gastroenterology
Volume	104
Issue number	3
DOIs	https://doi.org/10.1038/ajg.2009.23
Publication status	Published - Mar 2009

Keywords

genetics: Diseases in Twins
complications: Fatigue
Female
complications: Gastroesophageal Reflux
Health Status
Humans
genetics: Irritable Bowel Syndrome
Male
complications: Mental Disorders
Middle Aged
complications: Pain
Twins, Dizygotic
Twins, Monozygotic

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10.1038/ajg.2009.23

Cite this

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title = "Psychiatric disorder, irritable bowel syndrome, and extra-intestinal symptoms in a population-based sample of twins",

abstract = "OBJECTIVES: To determine, in a population-based sample of twin pairs, if extra-intestinal symptoms (EIS) are closely associated with both irritable bowel syndrome (IBS) and psychiatric disorders and whether such associations are explained on a genetic basis. METHODS: A random sample of twins between the ages of 44 and 64 years enrolled in the Minnesota Twins Registry completed the Modified Mayo Clinic Bowel Disease Questionnaire, a questionnaire on extra-intestinal symptoms, and the Psychiatric Diagnostic Screening Questionnaire. RESULTS: Of the 3,048 participants (51% response rate), 371 (12.2%) fulfilled Rome II criteria for IBS; 61 (16.4%) had a psychiatric disorder compared with 7.6% (n=204) of those without IBS (P",

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author = "Francis Creed and Lembo, {Anthony J.} and Mohammed Zaman and Krueger, {Robert F.} and Tomenson, {Barbara M.} and Creed, {Francis H.}",

year = "2009",

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language = "English",

volume = "104",

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issn = "0002-9270",

publisher = "Springer Nature",

number = "3",

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AU - Creed, Francis

AU - Lembo, Anthony J.

AU - Zaman, Mohammed

AU - Krueger, Robert F.

AU - Tomenson, Barbara M.

AU - Creed, Francis H.

PY - 2009/3

Y1 - 2009/3

N2 - OBJECTIVES: To determine, in a population-based sample of twin pairs, if extra-intestinal symptoms (EIS) are closely associated with both irritable bowel syndrome (IBS) and psychiatric disorders and whether such associations are explained on a genetic basis. METHODS: A random sample of twins between the ages of 44 and 64 years enrolled in the Minnesota Twins Registry completed the Modified Mayo Clinic Bowel Disease Questionnaire, a questionnaire on extra-intestinal symptoms, and the Psychiatric Diagnostic Screening Questionnaire. RESULTS: Of the 3,048 participants (51% response rate), 371 (12.2%) fulfilled Rome II criteria for IBS; 61 (16.4%) had a psychiatric disorder compared with 7.6% (n=204) of those without IBS (P

AB - OBJECTIVES: To determine, in a population-based sample of twin pairs, if extra-intestinal symptoms (EIS) are closely associated with both irritable bowel syndrome (IBS) and psychiatric disorders and whether such associations are explained on a genetic basis. METHODS: A random sample of twins between the ages of 44 and 64 years enrolled in the Minnesota Twins Registry completed the Modified Mayo Clinic Bowel Disease Questionnaire, a questionnaire on extra-intestinal symptoms, and the Psychiatric Diagnostic Screening Questionnaire. RESULTS: Of the 3,048 participants (51% response rate), 371 (12.2%) fulfilled Rome II criteria for IBS; 61 (16.4%) had a psychiatric disorder compared with 7.6% (n=204) of those without IBS (P

KW - genetics: Diseases in Twins

KW - complications: Fatigue

KW - Female

KW - complications: Gastroesophageal Reflux

KW - Health Status

KW - Humans

KW - genetics: Irritable Bowel Syndrome

KW - Male

KW - complications: Mental Disorders

KW - Middle Aged

KW - complications: Pain

KW - Twins, Dizygotic

KW - Twins, Monozygotic

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DO - 10.1038/ajg.2009.23

M3 - Article

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JO - The American Journal of Gastroenterology

JF - The American Journal of Gastroenterology

SN - 0002-9270

IS - 3

ER -

Psychiatric disorder, irritable bowel syndrome, and extra-intestinal symptoms in a population-based sample of twins

Abstract

Keywords

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