Psychiatric disorder, irritable bowel syndrome, and extra-intestinal symptoms in a population-based sample of twins

Francis Creed, Anthony J. Lembo, Mohammed Zaman, Robert F. Krueger, Barbara M. Tomenson, Francis H. Creed

    Research output: Contribution to journalArticlepeer-review

    Abstract

    OBJECTIVES: To determine, in a population-based sample of twin pairs, if extra-intestinal symptoms (EIS) are closely associated with both irritable bowel syndrome (IBS) and psychiatric disorders and whether such associations are explained on a genetic basis. METHODS: A random sample of twins between the ages of 44 and 64 years enrolled in the Minnesota Twins Registry completed the Modified Mayo Clinic Bowel Disease Questionnaire, a questionnaire on extra-intestinal symptoms, and the Psychiatric Diagnostic Screening Questionnaire. RESULTS: Of the 3,048 participants (51% response rate), 371 (12.2%) fulfilled Rome II criteria for IBS; 61 (16.4%) had a psychiatric disorder compared with 7.6% (n=204) of those without IBS (P
    Original languageEnglish
    Pages (from-to)686-694
    Number of pages8
    JournalAmerican Journal Of Gastroenterology
    Volume104
    Issue number3
    DOIs
    Publication statusPublished - Mar 2009

    Keywords

    • genetics: Diseases in Twins
    • complications: Fatigue
    • Female
    • complications: Gastroesophageal Reflux
    • Health Status
    • Humans
    • genetics: Irritable Bowel Syndrome
    • Male
    • complications: Mental Disorders
    • Middle Aged
    • complications: Pain
    • Twins, Dizygotic
    • Twins, Monozygotic

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