Puerperal affective psychosis: is there a case for lithium prophylaxis?

M McKenzie, J F Deakin

Research output: Contribution to journalArticlepeer-review


It is well known that women with a history of manic-depressive or puerperal affective psychosis are at particularly high risk of relapse in the puerperium. This paper describes the use of lithium given during or after pregnancy to women with a history of bipolar illness or puerperal affective psychosis. The rate of puerperal relapse in these subjects was compared with that in a similar group of women not on lithium. The significantly better outcome of the treatment group highlights the need for a prospective controlled trial looking at the effectiveness of lithium in minimising puerperal bipolar relapse.
Original languageEnglish
Pages (from-to)564-5
Number of pages2
JournalThe British journal of psychiatry : the journal of mental science
Publication statusPublished - Apr 1993


  • Adult
  • Bipolar Disorder
  • Drug Administration Schedule
  • Female
  • Follow-Up Studies
  • Humans
  • Lithium
  • Puerperal Disorders
  • Recurrence
  • Comment
  • Letter


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