Pulmonary epithelial permeability after inhaled distilled water 'fog'

T. Higenbottam, C. Borland, B. Barber, A. Chamberlain

Research output: Contribution to journalArticlepeer-review


The distinction between asthmatic and normal lung epithelium is that the changes induced by hypotonic solutions are associated in asthmatic patients with bronchoconstriction. It suggests that the trigger for bronchoconstriction is not at the epithelial surface, but either in the paracellular spaces or submucosa. Both these sites are likely to be exposed to the same changes in tonicity as the surfaces, if our observations on increased clearance of (99m)Tc DTPA do indeed reflect increased access to the paracellular spaces.

Original languageEnglish
Pages (from-to)156S-158S
Issue number5 SUPPL.
Publication statusPublished - 1 Jan 1985
Externally publishedYes


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