Pulmonary epithelial permeability after inhaling saline, distilled water 'fog' and cold air

C. Borland, A. Chamberlain, B. Barber, T. Higenbottam

    Research output: Contribution to journalArticlepeer-review

    Abstract

    It it recognized that hyperventilation of cold air and the inhalation of fine mists of distilled water provoke significant bronchoconstriction in the asthmatic individual, yet little is known as to how these provocations affect the structural integrity of the alveolar epithelial membrane. In 11 normal subjects, the following effects have been studied: cold air hyperventilation for three minutes, inhalation of 80 L of ultrasonically nebulized distilled water 'fog', and 80 L of isotonic saline 'fog' on the half time clearance (T 1/2 ) from the alveoli of technetium 99m diethylene triamine penta acetate (DTPA), inhaled as an aerosol. The DTPA T 1/2 provided a measurement of pulmonary epithelial permeability.
    Original languageEnglish
    Pages (from-to)373-376
    Number of pages3
    JournalChest
    Volume87
    Issue number3
    Publication statusPublished - 1985

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