Pulmonary interstitial fibrosis and haemosiderin-laden macrophages: Late following heart transplantation

J. J. Egan; N. Martin; P. S. Hasleton; N. Yonan; A. N. Rahman; C. A. Campbell; A. K. Deiraniya; K. B. Carroll; A. A. Woodcock

doi:10.1016/S0954-6111(96)90147-X

Pulmonary interstitial fibrosis and haemosiderin-laden macrophages: Late following heart transplantation

J. J. Egan, N. Martin, P. S. Hasleton, N. Yonan, A. N. Rahman, C. A. Campbell, A. K. Deiraniya, K. B. Carroll, A. A. Woodcock

Research output: Contribution to journal › Article › peer-review

Abstract

Impairment of pulmonary diffusion is recognized following heart transplantation. This study was undertaken to determine the histopathological basis for the defect in pulmonary physiology. Heart transplant recipients (HTR) entered into a prospective study of post-transplant pulmonary physiology were asked to undergo bronchoscopy, bronchoalveolar lavage (BAL) and transbronchial biopsy (n = 18) in the presence of impaired gas transfer. Transbronchial biopsies were examined under light microscopy and demonstrated focal interstitial fibrosis in 12 patients, cytomegalovirus disease in four patients and Pneumocystis carinii pneumonia in three patients. Bronchoalveolar lavage differential counts were normal in HTR but BAL macrophages contained haemosiderin. The histological features of interstitial fibrosis may underlie the fall in gas transfer seen following heart transplantation. The presence of haemosiderin-laden macrophages late following heart transplantation suggests a capillary leak syndrome.

Original language	English
Pages (from-to)	547-551
Number of pages	4
Journal	Respiratory Medicine
Volume	90
Issue number	9
DOIs	https://doi.org/10.1016/S0954-6111(96)90147-X
Publication status	Published - Oct 1996

Keywords

Bronchoalveolar Lavage
Bronchoscopy
complications: Cytomegalovirus Infections
Female
pathology: Heart Transplantation
metabolism: Hemosiderin
Humans
physiopathology: Lung
metabolism: Macrophages
Male
Middle Aged
complications: Pneumonia, Pneumocystis
Postoperative Period
Prospective Studies
complications: Pulmonary Fibrosis
Respiratory Function Tests

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0954-6111(96)90147-X

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title = "Pulmonary interstitial fibrosis and haemosiderin-laden macrophages: Late following heart transplantation",

abstract = "Impairment of pulmonary diffusion is recognized following heart transplantation. This study was undertaken to determine the histopathological basis for the defect in pulmonary physiology. Heart transplant recipients (HTR) entered into a prospective study of post-transplant pulmonary physiology were asked to undergo bronchoscopy, bronchoalveolar lavage (BAL) and transbronchial biopsy (n = 18) in the presence of impaired gas transfer. Transbronchial biopsies were examined under light microscopy and demonstrated focal interstitial fibrosis in 12 patients, cytomegalovirus disease in four patients and Pneumocystis carinii pneumonia in three patients. Bronchoalveolar lavage differential counts were normal in HTR but BAL macrophages contained haemosiderin. The histological features of interstitial fibrosis may underlie the fall in gas transfer seen following heart transplantation. The presence of haemosiderin-laden macrophages late following heart transplantation suggests a capillary leak syndrome.",

keywords = "Bronchoalveolar Lavage, Bronchoscopy, complications: Cytomegalovirus Infections, Female, pathology: Heart Transplantation, metabolism: Hemosiderin, Humans, physiopathology: Lung, metabolism: Macrophages, Male, Middle Aged, complications: Pneumonia, Pneumocystis, Postoperative Period, Prospective Studies, complications: Pulmonary Fibrosis, Respiratory Function Tests",

author = "Egan, {J. J.} and N. Martin and Hasleton, {P. S.} and N. Yonan and Rahman, {A. N.} and Campbell, {C. A.} and Deiraniya, {A. K.} and Carroll, {K. B.} and Woodcock, {A. A.}",

year = "1996",

month = oct,

doi = "10.1016/S0954-6111(96)90147-X",

language = "English",

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pages = "547--551",

journal = "Respiratory Medicine",

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T1 - Pulmonary interstitial fibrosis and haemosiderin-laden macrophages: Late following heart transplantation

AU - Egan, J. J.

AU - Martin, N.

AU - Hasleton, P. S.

AU - Yonan, N.

AU - Rahman, A. N.

AU - Campbell, C. A.

AU - Deiraniya, A. K.

AU - Carroll, K. B.

AU - Woodcock, A. A.

PY - 1996/10

Y1 - 1996/10

N2 - Impairment of pulmonary diffusion is recognized following heart transplantation. This study was undertaken to determine the histopathological basis for the defect in pulmonary physiology. Heart transplant recipients (HTR) entered into a prospective study of post-transplant pulmonary physiology were asked to undergo bronchoscopy, bronchoalveolar lavage (BAL) and transbronchial biopsy (n = 18) in the presence of impaired gas transfer. Transbronchial biopsies were examined under light microscopy and demonstrated focal interstitial fibrosis in 12 patients, cytomegalovirus disease in four patients and Pneumocystis carinii pneumonia in three patients. Bronchoalveolar lavage differential counts were normal in HTR but BAL macrophages contained haemosiderin. The histological features of interstitial fibrosis may underlie the fall in gas transfer seen following heart transplantation. The presence of haemosiderin-laden macrophages late following heart transplantation suggests a capillary leak syndrome.

AB - Impairment of pulmonary diffusion is recognized following heart transplantation. This study was undertaken to determine the histopathological basis for the defect in pulmonary physiology. Heart transplant recipients (HTR) entered into a prospective study of post-transplant pulmonary physiology were asked to undergo bronchoscopy, bronchoalveolar lavage (BAL) and transbronchial biopsy (n = 18) in the presence of impaired gas transfer. Transbronchial biopsies were examined under light microscopy and demonstrated focal interstitial fibrosis in 12 patients, cytomegalovirus disease in four patients and Pneumocystis carinii pneumonia in three patients. Bronchoalveolar lavage differential counts were normal in HTR but BAL macrophages contained haemosiderin. The histological features of interstitial fibrosis may underlie the fall in gas transfer seen following heart transplantation. The presence of haemosiderin-laden macrophages late following heart transplantation suggests a capillary leak syndrome.

KW - Bronchoalveolar Lavage

KW - Bronchoscopy

KW - complications: Cytomegalovirus Infections

KW - Female

KW - pathology: Heart Transplantation

KW - metabolism: Hemosiderin

KW - Humans

KW - physiopathology: Lung

KW - metabolism: Macrophages

KW - Male

KW - Middle Aged

KW - complications: Pneumonia, Pneumocystis

KW - Postoperative Period

KW - Prospective Studies

KW - complications: Pulmonary Fibrosis

KW - Respiratory Function Tests

U2 - 10.1016/S0954-6111(96)90147-X

DO - 10.1016/S0954-6111(96)90147-X

M3 - Article

C2 - 8984529

SN - 0954-6111

VL - 90

SP - 547

EP - 551

JO - Respiratory Medicine

JF - Respiratory Medicine

IS - 9

ER -

Pulmonary interstitial fibrosis and haemosiderin-laden macrophages: Late following heart transplantation

Abstract

Keywords

UN SDGs

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