Purified and isolated heparan sulfate 3-O-sulfotransferase isoform 5 nucleic acids and polypeptides and therapeutic and screening methods using same.

Jian Liu; Guoqing Xia; Jinghua Chen; Michael B. Duncan; Deepak Shukla; Vaibhav Tiwari; Anders Malmstrom

Purified and isolated heparan sulfate 3-O-sulfotransferase isoform 5 nucleic acids and polypeptides and therapeutic and screening methods using same.

Jian Liu (Other), Guoqing Xia (Other), Jinghua Chen (Other), Michael B. Duncan (Other), Deepak Shukla (Other), Vaibhav Tiwari (Other), Anders Malmstrom (Other)

Research output: Patent

Abstract

3-OST-5 proteins, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also disclosed, along with methods of producing each. Isolated and purified antibodies to 3-OST-5 homologs, and methods of producing the same, are also disclosed. 3OST-5 gene products have biological activity in specific heparan sulfate 3-O-sulfotransferase reactions. These reactions provide unique modified heparan sulfate. Thus, therapeutic methods involving this activity are also disclosed.

Original language	English
Patent number	WO2004005475
IPC	C12N 9/ 10 A I
Priority date	5/07/02
Publication status	Published - 12 May 2009

Keywords

heparan sulfate 3-O-sulfotransferase

Cite this

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title = "Purified and isolated heparan sulfate 3-O-sulfotransferase isoform 5 nucleic acids and polypeptides and therapeutic and screening methods using same.",

abstract = "3-OST-5 proteins, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also disclosed, along with methods of producing each. Isolated and purified antibodies to 3-OST-5 homologs, and methods of producing the same, are also disclosed. 3OST-5 gene products have biological activity in specific heparan sulfate 3-O-sulfotransferase reactions. These reactions provide unique modified heparan sulfate. Thus, therapeutic methods involving this activity are also disclosed.",

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author = "Jian Liu and Guoqing Xia and Jinghua Chen and Duncan, \{Michael B.\} and Deepak Shukla and Vaibhav Tiwari and Anders Malmstrom",

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day = "12",

language = "English",

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T1 - Purified and isolated heparan sulfate 3-O-sulfotransferase isoform 5 nucleic acids and polypeptides and therapeutic and screening methods using same.

A2 - Liu, Jian

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A2 - Chen, Jinghua

A2 - Duncan, Michael B.

A2 - Shukla, Deepak

A2 - Tiwari, Vaibhav

A2 - Malmstrom, Anders

PY - 2009/5/12

Y1 - 2009/5/12

N2 - 3-OST-5 proteins, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also disclosed, along with methods of producing each. Isolated and purified antibodies to 3-OST-5 homologs, and methods of producing the same, are also disclosed. 3OST-5 gene products have biological activity in specific heparan sulfate 3-O-sulfotransferase reactions. These reactions provide unique modified heparan sulfate. Thus, therapeutic methods involving this activity are also disclosed.

AB - 3-OST-5 proteins, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also disclosed, along with methods of producing each. Isolated and purified antibodies to 3-OST-5 homologs, and methods of producing the same, are also disclosed. 3OST-5 gene products have biological activity in specific heparan sulfate 3-O-sulfotransferase reactions. These reactions provide unique modified heparan sulfate. Thus, therapeutic methods involving this activity are also disclosed.

KW - heparan sulfate 3-O-sulfotransferase

M3 - Patent

M1 - WO2004005475

ER -

Purified and isolated heparan sulfate 3-O-sulfotransferase isoform 5 nucleic acids and polypeptides and therapeutic and screening methods using same.

Abstract

Keywords

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