TY - JOUR
T1 - Purinergic and glutamatergic receptors on astroglia
AU - Verkhratsky, A
AU - Burnstock, G
N1 - Verkhratsky, Alexei Burnstock, Geoffrey Adv Neurobiol. 2014;11:55-79. doi: 10.1007/978-3-319-08894-5_4.
PY - 2014
Y1 - 2014
N2 - Astroglial cells express many neurotransmitter receptors; the receptors to glutamate and ATP being the most abundant. Here, we provide a concise overview on the expression and main properties of astroglial glutamate receptors (ionotropic receptors represented by AMPA and NMDA subtypes) and metabotropic (mainly mGluR5 and mGluR3 subtypes) and purinoceptors (adenosine receptors of A1, A2A, A2B, and A3 types, ionotropic P2X1/5 and P2X7 subtypes, and metabotropic P2Y purinoceptors). We also discuss the role of these receptors in glial physiology and pathophysiology.
AB - Astroglial cells express many neurotransmitter receptors; the receptors to glutamate and ATP being the most abundant. Here, we provide a concise overview on the expression and main properties of astroglial glutamate receptors (ionotropic receptors represented by AMPA and NMDA subtypes) and metabotropic (mainly mGluR5 and mGluR3 subtypes) and purinoceptors (adenosine receptors of A1, A2A, A2B, and A3 types, ionotropic P2X1/5 and P2X7 subtypes, and metabotropic P2Y purinoceptors). We also discuss the role of these receptors in glial physiology and pathophysiology.
U2 - 10.1007/978-3-319-08894-5_4
DO - 10.1007/978-3-319-08894-5_4
M3 - Article
C2 - 25236724
SN - 2190-5215
VL - 11
SP - 55
EP - 79
JO - Advances in Neurobiology
JF - Advances in Neurobiology
ER -