Pyridoxine in atopic dermatitis

D. C. Mabin, S. Hollis, J. Lockwood, T. J. David

    Research output: Contribution to journalArticlepeer-review


    A previous study has reported benefit when pyridoxine hydrochloride was given to patients with atopic dermatitis. To investigate this in children, we performed a randomized, double-blind, parallel group, placebo-controlled trial. Forty-eight children with moderate or severe atopic dermatitis were recruited and, of those who completed the study, 19 received pyridoxine hydrochloride 50 mg once daily for 4 weeks and 22 received placebo. Disease activity was monitored by clinical severity scores measuring the extent and degrees of erythema recorded by the investigator and symptom scores (daytime itch and nocturnal sleep disturbance) recorded by parents. There was no statistically significant difference between the two groups at the end of treatment. We have been unable to demonstrate clinical benefit from pyridoxine supplementation in children with atopic dermatitis.
    Original languageEnglish
    Pages (from-to)764-767
    Number of pages4
    JournalBritish Journal of Dermatology
    Issue number5
    Publication statusPublished - 1995


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