QT prolongation in patients with Type 2 diabetes and microalbuminuria

Martin K. Rutter; Sathyamurthy Viswanath; Janet M. McComb; Patrick Kesteven; Sally M. Marshall

doi:10.1007/s10286-002-0036-8

QT prolongation in patients with Type 2 diabetes and microalbuminuria

Martin K. Rutter, Sathyamurthy Viswanath, Janet M. McComb, Patrick Kesteven, Sally M. Marshall

Research output: Contribution to journal › Article › peer-review

Abstract

The link between microalbuminuria and premature death in Type 2 diabetes is not fully explained by conventional cardiovascular risk factors. We aimed to determine if QT prolongation and/or dispersion are linked to microalbuminuria in patients with Type 2 diabetes and to investigate their associations with other risk factors. We have studied asymptomatic patients with Type 2 diabetes with no clinical evidence of coronary disease (43 with microalbuminuria matched with 43 normoalbuminuric patients). Rate-corrected maximum QT interval (QTc max was greater in the microalbuminuric group [mean (SD): 450 (23) vs 440 (20) ms1/2, p = 0.046] as was the proportion of (patients with QTc max > 440 ms) (67% vs 38%, p = 0.01). Rate-corrected QT dispersion (QTcd was similar in the two groups [57 (21) vs 53 (23) ms1/2, p = 0.41]. Linear regression analysis showed that QTc max and/or QTcd were not strongly linked to albumin excretion rate but more strongly to factors associated with microalbuminuria such as blood pressure and factor XIIa. Our findings support the hypothesis that QT prolongation and microalbuminuria have common determinants in Type 2 diabetes. QT prolongation may contribute to the increased mortality observed in microalbuminuric subjects with type 2 diabetes.

Original language	English
Pages (from-to)	366-372
Number of pages	6
Journal	Clinical Autonomic Research
Volume	12
Issue number	5
DOIs	https://doi.org/10.1007/s10286-002-0036-8
Publication status	Published - 2002

Keywords

Coronary risk
Maximum QT
Microalbuminuria
QT dispersion
QT prolongation
Type 2 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10286-002-0036-8

Cite this

@article{078b9cf897654d8fa32132daad0b53bf,

title = "QT prolongation in patients with Type 2 diabetes and microalbuminuria",

abstract = "The link between microalbuminuria and premature death in Type 2 diabetes is not fully explained by conventional cardiovascular risk factors. We aimed to determine if QT prolongation and/or dispersion are linked to microalbuminuria in patients with Type 2 diabetes and to investigate their associations with other risk factors. We have studied asymptomatic patients with Type 2 diabetes with no clinical evidence of coronary disease (43 with microalbuminuria matched with 43 normoalbuminuric patients). Rate-corrected maximum QT interval (QTc max was greater in the microalbuminuric group [mean (SD): 450 (23) vs 440 (20) ms1/2, p = 0.046] as was the proportion of (patients with QTc max > 440 ms) (67% vs 38%, p = 0.01). Rate-corrected QT dispersion (QTcd was similar in the two groups [57 (21) vs 53 (23) ms1/2, p = 0.41]. Linear regression analysis showed that QTc max and/or QTcd were not strongly linked to albumin excretion rate but more strongly to factors associated with microalbuminuria such as blood pressure and factor XIIa. Our findings support the hypothesis that QT prolongation and microalbuminuria have common determinants in Type 2 diabetes. QT prolongation may contribute to the increased mortality observed in microalbuminuric subjects with type 2 diabetes.",

keywords = "Coronary risk, Maximum QT, Microalbuminuria, QT dispersion, QT prolongation, Type 2 diabetes",

author = "Rutter, {Martin K.} and Sathyamurthy Viswanath and McComb, {Janet M.} and Patrick Kesteven and Marshall, {Sally M.}",

year = "2002",

doi = "10.1007/s10286-002-0036-8",

language = "English",

volume = "12",

pages = "366--372",

journal = "Clinical Autonomic Research",

issn = "1619-1560",

publisher = "Springer Nature",

number = "5",

}

TY - JOUR

T1 - QT prolongation in patients with Type 2 diabetes and microalbuminuria

AU - Rutter, Martin K.

AU - Viswanath, Sathyamurthy

AU - McComb, Janet M.

AU - Kesteven, Patrick

AU - Marshall, Sally M.

PY - 2002

Y1 - 2002

N2 - The link between microalbuminuria and premature death in Type 2 diabetes is not fully explained by conventional cardiovascular risk factors. We aimed to determine if QT prolongation and/or dispersion are linked to microalbuminuria in patients with Type 2 diabetes and to investigate their associations with other risk factors. We have studied asymptomatic patients with Type 2 diabetes with no clinical evidence of coronary disease (43 with microalbuminuria matched with 43 normoalbuminuric patients). Rate-corrected maximum QT interval (QTc max was greater in the microalbuminuric group [mean (SD): 450 (23) vs 440 (20) ms1/2, p = 0.046] as was the proportion of (patients with QTc max > 440 ms) (67% vs 38%, p = 0.01). Rate-corrected QT dispersion (QTcd was similar in the two groups [57 (21) vs 53 (23) ms1/2, p = 0.41]. Linear regression analysis showed that QTc max and/or QTcd were not strongly linked to albumin excretion rate but more strongly to factors associated with microalbuminuria such as blood pressure and factor XIIa. Our findings support the hypothesis that QT prolongation and microalbuminuria have common determinants in Type 2 diabetes. QT prolongation may contribute to the increased mortality observed in microalbuminuric subjects with type 2 diabetes.

AB - The link between microalbuminuria and premature death in Type 2 diabetes is not fully explained by conventional cardiovascular risk factors. We aimed to determine if QT prolongation and/or dispersion are linked to microalbuminuria in patients with Type 2 diabetes and to investigate their associations with other risk factors. We have studied asymptomatic patients with Type 2 diabetes with no clinical evidence of coronary disease (43 with microalbuminuria matched with 43 normoalbuminuric patients). Rate-corrected maximum QT interval (QTc max was greater in the microalbuminuric group [mean (SD): 450 (23) vs 440 (20) ms1/2, p = 0.046] as was the proportion of (patients with QTc max > 440 ms) (67% vs 38%, p = 0.01). Rate-corrected QT dispersion (QTcd was similar in the two groups [57 (21) vs 53 (23) ms1/2, p = 0.41]. Linear regression analysis showed that QTc max and/or QTcd were not strongly linked to albumin excretion rate but more strongly to factors associated with microalbuminuria such as blood pressure and factor XIIa. Our findings support the hypothesis that QT prolongation and microalbuminuria have common determinants in Type 2 diabetes. QT prolongation may contribute to the increased mortality observed in microalbuminuric subjects with type 2 diabetes.

KW - Coronary risk

KW - Maximum QT

KW - Microalbuminuria

KW - QT dispersion

KW - QT prolongation

KW - Type 2 diabetes

U2 - 10.1007/s10286-002-0036-8

DO - 10.1007/s10286-002-0036-8

M3 - Article

C2 - 12420081

SN - 1619-1560

VL - 12

SP - 366

EP - 372

JO - Clinical Autonomic Research

JF - Clinical Autonomic Research

IS - 5

ER -

QT prolongation in patients with Type 2 diabetes and microalbuminuria

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this