Quality of INR control and outcomes following venous thromboembolism.

Tjeerd Van Staa; Arlene M Gallagher; Frank de Vries; Jonathan M Plumb; Bastian Haß; Andreas Clemens; Tjeerd-Pieter van Staa

doi:10.1177/1076029611426139

Quality of INR control and outcomes following venous thromboembolism.

Tjeerd Van Staa, Arlene M Gallagher, Frank de Vries, Jonathan M Plumb, Bastian Haß, Andreas Clemens, Tjeerd-Pieter van Staa

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Abstract

INTRODUCTION: The objective of this study was to evaluate the pattern of anticoagulation after venous thromboembolism (VTE) in actual clinical practice. MATERIAL AND METHODS: This study used the General Practice Research Database. Individuals aged 18+ years with VTE were matched to 3 controls. RESULTS: Of the 46 335 patients with VTE and 138 024 controls, 70.2% of cases and 86.6% of controls had no obvious risk factors. The mortality risk was increased substantially around the time of diagnosis (relative hazard rate [RR] around 21) but remained elevated for a further 4 years (RRs around 1.5-2.0). The mean percentage of time spent within the therapeutic range for international normalized ratio (INR) was 57.0%. The lowest rate of VTE recurrence occurred in patients with ≥70% time spent within therapeutic range (RR of 0.50, 95% CI 0.39-0.63 compared to

Original language	English
Journal	Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Volume	18
Issue number	4
DOIs	https://doi.org/10.1177/1076029611426139
Publication status	Published - Jul 2012

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10.1177/1076029611426139

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title = "Quality of INR control and outcomes following venous thromboembolism.",

abstract = "INTRODUCTION: The objective of this study was to evaluate the pattern of anticoagulation after venous thromboembolism (VTE) in actual clinical practice. MATERIAL AND METHODS: This study used the General Practice Research Database. Individuals aged 18+ years with VTE were matched to 3 controls. RESULTS: Of the 46 335 patients with VTE and 138 024 controls, 70.2% of cases and 86.6% of controls had no obvious risk factors. The mortality risk was increased substantially around the time of diagnosis (relative hazard rate [RR] around 21) but remained elevated for a further 4 years (RRs around 1.5-2.0). The mean percentage of time spent within the therapeutic range for international normalized ratio (INR) was 57.0%. The lowest rate of VTE recurrence occurred in patients with ≥70% time spent within therapeutic range (RR of 0.50, 95% CI 0.39-0.63 compared to",

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T1 - Quality of INR control and outcomes following venous thromboembolism.

AU - Van Staa, Tjeerd

AU - Gallagher, Arlene M

AU - de Vries, Frank

AU - Plumb, Jonathan M

AU - Haß, Bastian

AU - Clemens, Andreas

AU - van Staa, Tjeerd-Pieter

PY - 2012/7

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N2 - INTRODUCTION: The objective of this study was to evaluate the pattern of anticoagulation after venous thromboembolism (VTE) in actual clinical practice. MATERIAL AND METHODS: This study used the General Practice Research Database. Individuals aged 18+ years with VTE were matched to 3 controls. RESULTS: Of the 46 335 patients with VTE and 138 024 controls, 70.2% of cases and 86.6% of controls had no obvious risk factors. The mortality risk was increased substantially around the time of diagnosis (relative hazard rate [RR] around 21) but remained elevated for a further 4 years (RRs around 1.5-2.0). The mean percentage of time spent within the therapeutic range for international normalized ratio (INR) was 57.0%. The lowest rate of VTE recurrence occurred in patients with ≥70% time spent within therapeutic range (RR of 0.50, 95% CI 0.39-0.63 compared to

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Quality of INR control and outcomes following venous thromboembolism.

Abstract

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