Quantification in positron emission tomography for research in pharmacology and drug development

V. J. Cunningham, R. N. Gunn, J. C. Matthews

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Positron emission tomography (PET) is a quantitative in vivo tracer technique, enabling images of the distribution of biochemical, physiological and pharmacological functions in living tissue, at a resolution of a few millimetres. Applications include the imaging of blood flow rate, metabolic rate and neuroreceptor distribution and function. These applications are playing an increasing role in drug development. This brief article seeks to emphasize how these applications of PET need to rest on a solid quantitative foundation. © 2004 Lippincott Williams & Wilkins.
    Original languageEnglish
    Pages (from-to)643-646
    Number of pages3
    JournalNuclear Medicine Communications
    Volume25
    Issue number7
    DOIs
    Publication statusPublished - Jul 2004

    Keywords

    • Blood flow
    • Metabolic rate for glucose
    • Neuroreceptor function
    • Positron emission tomography
    • Quantification

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