Quantification of lung metastases from in vivo mouse models

Joan Chang; Janine T. Erler

doi:10.1007/978-3-319-26666-4_14

Quantification of lung metastases from in vivo mouse models

Joan Chang, Janine T. Erler

Division of Cell Matrix Biology & Regenerative Medicine (L5)

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Cancer research has made significant progress in terms of understanding and targeting primary tumors; however, the challenge remains for the successful treatment of metastatic cancers. This highlights the importance to use in vivo models to study the metastatic process, as well as for preclinical testing of compounds that could inhibit metastasis. As a result, proper quantification of metastases from in vivo models is of the utmost significance. Here, we provide a detailed protocol for collecting and handling lung tissues from mice, and guidance for subsequent analysis of metastases, as well as interpretation of data.

Original language	English
Title of host publication	Tumor microenvironment
Subtitle of host publication	study protocols
Editors	Constantinos Koumenis, Lisa M. Coussens, Amato Giaccia, Ester Hammond
Place of Publication	Cham
Publisher	Springer Nature
Chapter	14
Pages	245-251
Number of pages	7
ISBN (Electronic)	9783319266664
ISBN (Print)	9783319266640
DOIs	https://doi.org/10.1007/978-3-319-26666-4_14
Publication status	Published - 2016

Keywords

Quantification
Metastasis
In vivo model
Tissue collection
ImageJ

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-3-319-26666-4_14

Cite this

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KW - Tissue collection

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Quantification of lung metastases from in vivo mouse models

Abstract

Keywords

UN SDGs

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