Abstract
Estimates of adherence to antihypertensive treatment in pregnancy are limited; identifying non-adherence could facilitate intervention and optimise blood pressure control. This study aimed to evaluate adherence to antihypertensive treatment amongst pregnant women with chronic hypertension using high-performance liquid chromatography-tandem mass spectrometry instrumentation. Spot urine samples collected from women who were randomised to labetalol or nifedipine were assessed. Samples from 74 women were included; documented prescribing and urine metabolite detection were concordant in 88% (n = 65). Evidence of self-administration of alternative treatment was observed in 8% (n = 6). Measurement of urinary antihypertensive metabolites in pregnancy provides insight into treatment adherence.
Original language | English |
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Pages (from-to) | 12-14 |
Number of pages | 3 |
Journal | Pregnancy Hypertension |
Volume | 17 |
Early online date | 3 May 2019 |
DOIs | |
Publication status | Published - 1 Jul 2019 |
Keywords
- Adherence
- Antihypertensive treatment
- Chronic Hypertension
- Pregnancy