Quantitative measurement of single cell dynamics

Denise Bakstad; Antony Adamson; David G. Spiller; Michael R H White

doi:10.1016/j.copbio.2011.11.007

Quantitative measurement of single cell dynamics

Denise Bakstad
, Antony Adamson
, David G. Spiller
, Michael R H White^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Over the past 20 years luminescent and fluorescent imaging assays have been developed to report on the dynamics of transcription and protein translocation in single cells. The combination of these measurements with mathematical analysis is having an increasingly significant impact on cell biology. There is an urgent need to translate these assays to the study of cells and tissues in vivo, which requires new tools and technologies. Emergence of these new tools and techniques will further the understanding of the role of signalling and transcriptional dynamics in the generation of cellular heterogeneity and the control of cell fate. © 2011 Elsevier Ltd.

Original language	English
Pages (from-to)	103-109
Number of pages	7
Journal	Current Opinion in Biotechnology
Volume	23
Issue number	1
Early online date	30 Nov 2011
DOIs	https://doi.org/10.1016/j.copbio.2011.11.007
Publication status	Published - Feb 2012

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10.1016/j.copbio.2011.11.007

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title = "Quantitative measurement of single cell dynamics",

abstract = "Over the past 20 years luminescent and fluorescent imaging assays have been developed to report on the dynamics of transcription and protein translocation in single cells. The combination of these measurements with mathematical analysis is having an increasingly significant impact on cell biology. There is an urgent need to translate these assays to the study of cells and tissues in vivo, which requires new tools and technologies. Emergence of these new tools and techniques will further the understanding of the role of signalling and transcriptional dynamics in the generation of cellular heterogeneity and the control of cell fate. {\textcopyright} 2011 Elsevier Ltd.",

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AU - Bakstad, Denise

AU - Adamson, Antony

AU - Spiller, David G.

AU - White, Michael R H

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N2 - Over the past 20 years luminescent and fluorescent imaging assays have been developed to report on the dynamics of transcription and protein translocation in single cells. The combination of these measurements with mathematical analysis is having an increasingly significant impact on cell biology. There is an urgent need to translate these assays to the study of cells and tissues in vivo, which requires new tools and technologies. Emergence of these new tools and techniques will further the understanding of the role of signalling and transcriptional dynamics in the generation of cellular heterogeneity and the control of cell fate. © 2011 Elsevier Ltd.

AB - Over the past 20 years luminescent and fluorescent imaging assays have been developed to report on the dynamics of transcription and protein translocation in single cells. The combination of these measurements with mathematical analysis is having an increasingly significant impact on cell biology. There is an urgent need to translate these assays to the study of cells and tissues in vivo, which requires new tools and technologies. Emergence of these new tools and techniques will further the understanding of the role of signalling and transcriptional dynamics in the generation of cellular heterogeneity and the control of cell fate. © 2011 Elsevier Ltd.

U2 - 10.1016/j.copbio.2011.11.007

DO - 10.1016/j.copbio.2011.11.007

M3 - Article

SN - 0958-1669

VL - 23

SP - 103

EP - 109

JO - Current Opinion in Biotechnology

JF - Current Opinion in Biotechnology

IS - 1

ER -

Quantitative measurement of single cell dynamics

Abstract

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