Quantitative nailfold video capillaroscopy in patients with idiopathic inflammatory myopathy

Louise K. Mercer, Tonia L. Moore, Hector Chinoy, Andrea K. Murray, Andy Vail, Robert G. Cooper, Ariane L. Herrick

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    Abstract

    Objectives. To quantify nailfold capillary density and dimensions in patients with idiopathic inflammatory myopathy (IIM) and compare them with those in healthy controls; to look for associations with microvascular disease in IIM; and to determine whether nailfold capillary density and dimensions change over time. Methods. Nailfold video microscopy (×300 magnification) was performed on 24 patients with IIM and 35 healthy controls. Capillary density and dimensions (total width and apical width) were quantified. Patients were clinically assessed and disease activity recorded using the Myositis Disease Activity Assessment Tool. Disease severity and physical function were assessed using the myositis damage index and Stanford HAQ, respectively. Findings were analysed using linear and logistic regression, adjusted for age and sex. In a subgroup of 16 patients with IIM and 27 controls, the process was repeated 6-12 months later and the results were analysed using Student's t-test. Results. Capillary density was lower and dimensions were higher in patients with IIM compared with healthy controls (P
    Original languageEnglish
    Article numberkeq051
    Pages (from-to)1699-1705
    Number of pages6
    JournalRheumatology
    Volume49
    Issue number9
    DOIs
    Publication statusPublished - 18 May 2010

    Keywords

    • Dermatomyositis
    • Nailfold video capillaroscopy
    • Polymyositis

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