Quantitative Surface Analysis of a Binary Drug Mixture Suppression Effects in the Detection of Sputtered Ions and Post-Ionized Neutrals

Gabriel Karras; Nicholas P Lockyer

doi:10.1007/s13361-014-0847-6

Quantitative Surface Analysis of a Binary Drug Mixture Suppression Effects in the Detection of Sputtered Ions and Post-Ionized Neutrals

Gabriel Karras, Nicholas P Lockyer

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Abstract

A systematic mass spectrometric study of two of the most common analgesic drugs, paracetamol and ibuprofen, is reported. The drugs were studied by means of secondary ion mass spectrometry (SIMS) and secondary neutral mass spectrometry (SNMS) using laser post-ionization (LPI) both in pure samples and in a two-component mixture. Ion suppression within the two-component system observed in SIMS mode is ameliorated using LPI under room temperature analysis. However, suppression effects are apparent in LPI mode on performing the analysis at cryogenic temperatures, which we attribute to changes in the desorption characteristics of sputtered molecules, which influences the subsequent post-ionization efficiency. This suggests different mechanisms of ion suppression in SIMS and LPI modes.

Original language	English
Pages (from-to)	832-840
Number of pages	8
Journal	American Society for Mass Spectrometry. Journal
Volume	25
Issue number	5
Early online date	22 Mar 2014
DOIs	https://doi.org/10.1007/s13361-014-0847-6
Publication status	Published - May 2014

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title = "Quantitative Surface Analysis of a Binary Drug Mixture Suppression Effects in the Detection of Sputtered Ions and Post-Ionized Neutrals",

abstract = "A systematic mass spectrometric study of two of the most common analgesic drugs, paracetamol and ibuprofen, is reported. The drugs were studied by means of secondary ion mass spectrometry (SIMS) and secondary neutral mass spectrometry (SNMS) using laser post-ionization (LPI) both in pure samples and in a two-component mixture. Ion suppression within the two-component system observed in SIMS mode is ameliorated using LPI under room temperature analysis. However, suppression effects are apparent in LPI mode on performing the analysis at cryogenic temperatures, which we attribute to changes in the desorption characteristics of sputtered molecules, which influences the subsequent post-ionization efficiency. This suggests different mechanisms of ion suppression in SIMS and LPI modes.",

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AB - A systematic mass spectrometric study of two of the most common analgesic drugs, paracetamol and ibuprofen, is reported. The drugs were studied by means of secondary ion mass spectrometry (SIMS) and secondary neutral mass spectrometry (SNMS) using laser post-ionization (LPI) both in pure samples and in a two-component mixture. Ion suppression within the two-component system observed in SIMS mode is ameliorated using LPI under room temperature analysis. However, suppression effects are apparent in LPI mode on performing the analysis at cryogenic temperatures, which we attribute to changes in the desorption characteristics of sputtered molecules, which influences the subsequent post-ionization efficiency. This suggests different mechanisms of ion suppression in SIMS and LPI modes.

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Quantitative Surface Analysis of a Binary Drug Mixture Suppression Effects in the Detection of Sputtered Ions and Post-Ionized Neutrals

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