Radical heterocyclization and heterocyclization cascades triggered by electron transfer to amide-type carbonyls

Huanming Huang, David Procter

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    Abstract

    Radical heterocyclizations triggered by electron transfer to amide-type carbonyls using SmI2-H2O provides straightforward access to bicyclic heterocyclic scaffolds containing bridgehead nitrogens. Furthermore, the first radical heterocyclization cascades triggered by reduction of amide-type carbonyls deliver novel,
    complex tetracyclic architectures containing five contiguous stereocenters with excellent diastereocontrol.
    Original languageEnglish
    Pages (from-to)14262-14266
    Number of pages5
    JournalAngewandte Chemie
    Volume56
    Issue number45
    Early online date13 Oct 2017
    DOIs
    Publication statusPublished - 26 Dec 2017

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