Radiobiology at ultra-high dose rates employing laser-driven ions

F Hanton; D Doria; KF Kakolee; S Kar; SK Litt; H Ahmed; CL Lewis; G Nersisyan; R Prasad; M Zepf; M Borghesi; F Fiorini; D Kirby; S Green; JCG Jeynes; KJ Kirkby; MJ Merchant; J Kavanagh; KM Prise; G Schettino

doi:10.1117/12.2017565

Radiobiology at ultra-high dose rates employing laser-driven ions

F Hanton, D Doria, KF Kakolee, S Kar, SK Litt, H Ahmed, CL Lewis, G Nersisyan, R Prasad, M Zepf, M Borghesi, F Fiorini, D Kirby, S Green, JCG Jeynes, KJ Kirkby, MJ Merchant, J Kavanagh, KM Prise, G Schettino

Research output: Contribution to journal › Article › peer-review

Abstract

The potential that laser based particle accelerators offer to solve sizing and cost issues arising with conventional proton therapy has generated great interest in the understanding and development of laser ion acceleration, and in investigating the radiobiological effects induced by laser accelerated ions. Laser-driven ions are produced in bursts of ultra-short duration resulting in ultra-high dose rates, and an investigation at Queen's University Belfast was carried out to investigate this virtually unexplored regime of cell rdaiobiology. This employed the TARANIS terawatt laser producing protons in the MeV range for proton irradiation, with dose rates exceeding 10 Gys on a single exposure. A clonogenic assay was implemented to analyse the biological effect of proton irradiation on V79 cells, which, when compared to data obtained with the same cell line irradiated with conventionally accelerated protons, was found to show no significant difference. A Relative Biological effectiveness of 1.4??0.2 at 10 % Survival Fraction was estimated from a comparison with a 225 kVp X-ray source. ?? 2013 SPIE.

Original language	English
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	8779
DOIs	https://doi.org/10.1117/12.2017565
Publication status	Published - 2013

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Hanton, F., Doria, D., Kakolee, KF., Kar, S., Litt, SK., Ahmed, H., Lewis, CL., Nersisyan, G., Prasad, R., Zepf, M., Borghesi, M., Fiorini, F., Kirby, D., Green, S., Jeynes, JCG., Kirkby, KJ., Merchant, MJ., Kavanagh, J., Prise, KM., & Schettino, G. (2013). Radiobiology at ultra-high dose rates employing laser-driven ions. Proceedings of SPIE - The International Society for Optical Engineering, 8779. https://doi.org/10.1117/12.2017565

@article{a351b6e1cea349269c388a033cb66aa4,

title = "Radiobiology at ultra-high dose rates employing laser-driven ions",

abstract = "The potential that laser based particle accelerators offer to solve sizing and cost issues arising with conventional proton therapy has generated great interest in the understanding and development of laser ion acceleration, and in investigating the radiobiological effects induced by laser accelerated ions. Laser-driven ions are produced in bursts of ultra-short duration resulting in ultra-high dose rates, and an investigation at Queen's University Belfast was carried out to investigate this virtually unexplored regime of cell rdaiobiology. This employed the TARANIS terawatt laser producing protons in the MeV range for proton irradiation, with dose rates exceeding 10 Gys on a single exposure. A clonogenic assay was implemented to analyse the biological effect of proton irradiation on V79 cells, which, when compared to data obtained with the same cell line irradiated with conventionally accelerated protons, was found to show no significant difference. A Relative Biological effectiveness of 1.4??0.2 at 10 % Survival Fraction was estimated from a comparison with a 225 kVp X-ray source. ?? 2013 SPIE.",

author = "F Hanton and D Doria and KF Kakolee and S Kar and SK Litt and H Ahmed and CL Lewis and G Nersisyan and R Prasad and M Zepf and M Borghesi and F Fiorini and D Kirby and S Green and JCG Jeynes and KJ Kirkby and MJ Merchant and J Kavanagh and KM Prise and G Schettino",

year = "2013",

doi = "10.1117/12.2017565",

language = "English",

volume = "8779",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

publisher = "SPIE",

}

Hanton, F, Doria, D, Kakolee, KF, Kar, S, Litt, SK, Ahmed, H, Lewis, CL, Nersisyan, G, Prasad, R, Zepf, M, Borghesi, M, Fiorini, F, Kirby, D, Green, S, Jeynes, JCG, Kirkby, KJ, Merchant, MJ, Kavanagh, J, Prise, KM & Schettino, G 2013, 'Radiobiology at ultra-high dose rates employing laser-driven ions', Proceedings of SPIE - The International Society for Optical Engineering, vol. 8779. https://doi.org/10.1117/12.2017565

TY - JOUR

T1 - Radiobiology at ultra-high dose rates employing laser-driven ions

AU - Hanton, F

AU - Doria, D

AU - Kakolee, KF

AU - Kar, S

AU - Litt, SK

AU - Ahmed, H

AU - Lewis, CL

AU - Nersisyan, G

AU - Prasad, R

AU - Zepf, M

AU - Borghesi, M

AU - Fiorini, F

AU - Kirby, D

AU - Green, S

AU - Jeynes, JCG

AU - Kirkby, KJ

AU - Merchant, MJ

AU - Kavanagh, J

AU - Prise, KM

AU - Schettino, G

PY - 2013

Y1 - 2013

N2 - The potential that laser based particle accelerators offer to solve sizing and cost issues arising with conventional proton therapy has generated great interest in the understanding and development of laser ion acceleration, and in investigating the radiobiological effects induced by laser accelerated ions. Laser-driven ions are produced in bursts of ultra-short duration resulting in ultra-high dose rates, and an investigation at Queen's University Belfast was carried out to investigate this virtually unexplored regime of cell rdaiobiology. This employed the TARANIS terawatt laser producing protons in the MeV range for proton irradiation, with dose rates exceeding 10 Gys on a single exposure. A clonogenic assay was implemented to analyse the biological effect of proton irradiation on V79 cells, which, when compared to data obtained with the same cell line irradiated with conventionally accelerated protons, was found to show no significant difference. A Relative Biological effectiveness of 1.4??0.2 at 10 % Survival Fraction was estimated from a comparison with a 225 kVp X-ray source. ?? 2013 SPIE.

AB - The potential that laser based particle accelerators offer to solve sizing and cost issues arising with conventional proton therapy has generated great interest in the understanding and development of laser ion acceleration, and in investigating the radiobiological effects induced by laser accelerated ions. Laser-driven ions are produced in bursts of ultra-short duration resulting in ultra-high dose rates, and an investigation at Queen's University Belfast was carried out to investigate this virtually unexplored regime of cell rdaiobiology. This employed the TARANIS terawatt laser producing protons in the MeV range for proton irradiation, with dose rates exceeding 10 Gys on a single exposure. A clonogenic assay was implemented to analyse the biological effect of proton irradiation on V79 cells, which, when compared to data obtained with the same cell line irradiated with conventionally accelerated protons, was found to show no significant difference. A Relative Biological effectiveness of 1.4??0.2 at 10 % Survival Fraction was estimated from a comparison with a 225 kVp X-ray source. ?? 2013 SPIE.

U2 - 10.1117/12.2017565

DO - 10.1117/12.2017565

M3 - Article

VL - 8779

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

ER -

Radiobiology at ultra-high dose rates employing laser-driven ions

Abstract

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