Radiogenomics and radiotherapy response modeling.

Issam El Naqa, Catharine West

Research output: Contribution to journalArticlepeer-review


Advances in patient-specific information and biotechnology have contributed to a new era of computational medicine. Radiogenomics has emerged as a new field that investigates the role of genetics in treatment response to radiation therapy. Radiation oncology is currently attempting to embrace these recent advances and add to its rich history by maintaining its prominent role as a quantitative leader in oncologic response modeling. Here, we provide an overview of radiogenomics starting with genotyping, data aggregation, and application of different modeling approaches based on modifying traditional radiobiological methods or application of advanced machine learning techniques. We highlight the current status and potential for this new field to reshape the landscape of outcome modeling in radiotherapy and drive future advances in computational oncology.
Original languageEnglish
Pages (from-to)R179-R206
Number of pages7
JournalPhysics in Medicine and Biology
Issue number16
Publication statusPublished - 1 Aug 2017

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre


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